Which drugs cause birth defects?.

Choice A rationale:
An allergic reaction refers to an immune response to a foreign substance. It does not describe the interaction between an antacid and ketoconazole.
Choice B rationale:
Displacement refers to one drug replacing another at the drug-binding site on proteins, altering the distribution of the displaced drug. It does not describe the interaction between an antacid and ketoconazole.
Choice C rationale:
Accumulation refers to the buildup of a drug in the body due to inadequate metabolism or excretion. It does not describe the interaction between an antacid and ketoconazole.
Choice D rationale:
A drug interaction occurs when the effect of one drug is altered by the administration of another drug. Antacids can slow the dissolution and absorption of ketoconazole, which is a type of drug interaction.

Choice A rationale:
An increase in the amount of lipid-soluble drugs in the system can occur with decreased albumin and globulin levels, but it does not cause the most concern.
Choice B rationale:
Increased free protein-bound drugs available can lead to an increased potential for adverse drug reactions. This is because these drugs are usually more active and can lead to toxicity.
Choice C rationale:
Water-soluble drugs being absorbed more completely is not typically a concern with decreased albumin and globulin levels.
Choice D rationale:
While metabolism of protein-bound drugs may be decreased, leading to an increased potential for adverse reactions, this is not the primary concern with decreased albumin and globulin levels.