Which adverse effect unique to vancomycin is caused by histamine release?
Discoloration of body fluids
Ototoxicity
Red-man syndrome
Nephrotoxicity
The Correct Answer is C
A. Discoloration of body fluids:
Vancomycin can cause discoloration of body fluids, particularly urine, resulting in a brownish discoloration. However, this is not caused by histamine release.
B. Ototoxicity:
Ototoxicity refers to damage to the inner ear structures leading to hearing loss or balance problems. While vancomycin can cause ototoxicity, it is not specifically associated with histamine release.
C. Red-man syndrome
Red-man syndrome, also known as red-neck syndrome or red-person syndrome, is a hypersensitivity reaction characterized by flushing of the skin, particularly the upper body and face, resembling a "red man." This reaction is typically associated with the rapid infusion of vancomycin and is caused by the release of histamine from mast cells and basophils. It is not an allergic reaction but rather a non-immunologic response to vancomycin.
D. Nephrotoxicity:
Nephrotoxicity refers to kidney damage caused by certain medications or toxins. While vancomycin can cause nephrotoxicity, it is not specifically associated with histamine release.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
A. Echinacea:
Echinacea is an herbal supplement commonly used to support the immune system and reduce the severity and duration of cold symptoms. However, there is limited evidence to support its efficacy in preventing urinary tract infections (UTIs). While it may have some immune-boosting properties, it is not typically recommended specifically for UTI prevention.
B. Saw palmetto:
Saw palmetto is an herbal supplement often used for prostate health and to alleviate symptoms of benign prostatic hyperplasia (BPH) in men. It is not typically used for preventing urinary tract infections in either men or women.
C. Black cohosh:
Black cohosh is an herbal supplement commonly used by women to alleviate symptoms of menopause, such as hot flashes and mood swings. It is not typically used for preventing urinary tract infections.
D. Cranberry juice:
Cranberry juice and cranberry supplements have long been studied for their potential role in preventing urinary tract infections, particularly in women. Cranberry contains compounds that may prevent bacteria, such as Escherichia coli (E. coli), from adhering to the walls of the urinary tract, reducing the risk of infection. While the evidence supporting cranberry's effectiveness in preventing UTIs is mixed, some studies suggest that it may be beneficial, especially in individuals prone to recurrent UTIs.
Correct Answer is A
Explanation
A. Keep the serum drug level within the therapeutic margin:
This is the correct goal of monitoring peak and trough levels during antibacterial therapy. The therapeutic margin refers to the range of drug concentrations in the bloodstream that achieves optimal therapeutic effects while avoiding toxicity. By monitoring peak and trough levels, healthcare providers can adjust the dosing regimen to maintain drug levels within this therapeutic margin.
B. Increase the therapeutic effect of the drug by gradually decreasing the drug dose:
This statement is incorrect. Monitoring peak and trough levels is not about increasing the therapeutic effect of the drug by gradually decreasing the drug dose. Instead, it's about ensuring that the drug levels are maintained within the appropriate therapeutic range to achieve optimal efficacy without causing adverse effects.
C. Provide maximum physical comfort to the patient:
Monitoring peak and trough levels is not primarily aimed at providing physical comfort to the patient. While optimizing drug therapy can contribute to improved clinical outcomes and patient well-being, the goal of monitoring these levels is specifically related to achieving therapeutic drug concentrations.
D. Treat the main disorder with no psychological distress to the patient:
This statement is unrelated to the goal of monitoring peak and trough levels during antibacterial therapy. While psychological distress may be a consideration in patient care, the primary goal of monitoring drug levels is to ensure therapeutic efficacy and safety.
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