What is the primary pathophysiological process that occurs in disseminated intravascular coagulation (DIC)?
Decreased production of clotting factors
Impaired platelet function
Excessive activation of clotting factors and widespread clot formation
Excessive platelet production
The Correct Answer is C
A. DIC is not characterized by decreased production of clotting factors. Instead, it involves consumption of clotting factors due to widespread activation of coagulation.
B. While platelet dysfunction may occur in DIC due to consumption and depletion of platelets, the primary pathophysiological process in DIC is the activation of clotting factors and formation of blood clots throughout the vasculature.
C. Excessive activation of clotting factors and widespread clot formation is the primary pathophysiological process in DIC. This leads to the formation of numerous small blood clots throughout the body's blood vessels, resulting in organ dysfunction and potentially life-threatening complications.
D. Excessive platelet production is not a characteristic feature of DIC. Instead, platelets are consumed and depleted as they are incorporated into the blood clots formed during the
coagulation cascade in DIC.
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Related Questions
Correct Answer is ["C","D"]
Explanation
A. The patient experiences a decrease in hemoglobin S. Hydroxyurea does not decrease hemoglobin S levels directly; it works by increasing fetal hemoglobin (Hgb F) levels.
B. The patient experiences dehydration due to diuresis. This is not an indication that Hydroxyurea is working; it is a potential side effect that should be monitored.
C. The patient experiences an increase in fetal hemoglobin (Hbg F). Hydroxyurea works by increasing the levels of fetal hemoglobin, which reduces the sickling of red blood cells.
D. The patient needs fewer blood transfusions. Successful treatment with Hydroxyurea should reduce the frequency of vaso-occlusive crises and the need for blood transfusions.
E. The patient experiences diuresis. This is not an indicator of the medication's effectiveness; it is a potential side effect.
Correct Answer is ["A","B","G"]
Explanation
A. Severe pain is a hallmark manifestation of a sickle cell crisis due to vaso-occlusion and tissue ischemia.
B. Fever can occur during a sickle cell crisis, often indicating an underlying infection or inflammatory response.
C. Normal blood counts are not typical during a sickle cell crisis; patients often exhibit anemia, leukocytosis, and thrombocytosis.
D. Clear urine is not a common manifestation of a sickle cell crisis; hematuria or dark-colored urine may occur due to hemolysis or kidney damage.
E. Increased energy levels are not typical during a sickle cell crisis; patients often experience fatigue and malaise.
F. Normal oxygen saturation levels may occur in some patients during a sickle cell crisis, but it is not a consistent finding.
G. Jaundice is common in sickle cell crisis due to hemolysis of red blood cells, leading to an increase in bilirubin levels.
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