The nurse prepares to change a patient's medication from an intravenous to an oral form and notes that the oral form is ordered in a higher dose. The nurse understands that this is due to differences in

Bioavailability

Pinocytosis

Tachyphylaxis

Protein binding

Answer and Explanation

The Correct Answer is A

a) Bioavailability refers to the proportion of the drug that reaches systemic circulation when administered by a particular route. The oral route typically has lower bioavailability than the intravenous route due to the first-pass metabolism in the liver. Therefore, when switching from an IV form to an oral form, the dose often needs to be higher to achieve the same therapeutic effect.

b) Pinocytosis is a form of endocytosis where cells absorb fluids and small molecules. While important in drug absorption, it is not the reason why oral doses are higher than IV doses.

c) Tachyphylaxis is a rapid tolerance to a drug after its administration, often requiring higher doses over time, but it does not directly explain the need for a higher oral dose.

d) Protein binding refers to how drugs bind to proteins in the blood, which can affect their distribution. However, this is not the main reason why oral doses are higher than IV doses.

Nursing Test Bank

Quiz #1: RN Exams Pharmacology Exams Quiz #2: RN Exams Medical-Surgical Exams Quiz #3: RN Exams Fundamentals Exams Quiz #4: RN Exams Maternal-Newborn Exams Quiz #5: RN Exams Anatomy and Physiology Exams Quiz #6: RN Exams Obstetrics and Pediatrics Exams Quiz #7: RN Exams Fluid and Electrolytes Exams Quiz #8: RN Exams Community Health Exams Quiz #9: RN Exams Promoting Health across the lifespan Exams Quiz #10: RN Exams Multidimensional care Exams

Get 100+ Naxlex Exit Exams for $79 Try Naxlex NCLEX-RN (14 Day Free-Trial)

Naxlex Comprehensive Predictor Exams

Quiz #1: Naxlex RN Comprehensive online practice 2019 B with NGN Quiz #2: Naxlex RN Comprehensive Predictor 2023 Quiz #3: Naxlex RN Comprehensive Predictor 2023 Exit Exam A Quiz #4: Naxlex HESI Exit LPN Exam Quiz #5: Naxlex PN Comprehensive Predictor PN 2020 Quiz #6: Naxlex VATI PN Comprehensive Predictor 2020 Quiz #8: Naxlex PN Comprehensive Predictor 2023 - Exam 1 Quiz #10: Naxlex HESI PN Exit exam Quiz #11: Naxlex HESI PN EXIT Exam 2

Free Nursing Study Resources

Correct Answer is B

Explanation

a) Decreased drug effects are unlikely in liver disease because impaired liver function reduces drug metabolism, leading to higher drug concentrations in the bloodstream.

b) Increased drug effects occur because the liver is responsible for metabolizing many drugs. In liver disease, drug metabolism is slowed, leading to prolonged drug action and potential toxicity.

c) Decreased therapeutic range is not the primary concern. The therapeutic range refers to the safe and effective drug concentration, but liver disease mainly affects drug metabolism and clearance.

d) Increased therapeutic range is incorrect because liver disease does not widen the range of safe drug levels; instead, it increases the risk of drug accumulation and toxicity.

A. C-V B. C-II C. C-I D. C-III

Correct Answer is B

Explanation

A. C-V drugs are considered to have the lowest potential for abuse and are typically used for medications like cough preparations with less than 200 milligrams of codeine per 100 milliliters or per 100 grams. Methadone is not classified under C-V.

B. Methadone is classified as a C-II (Schedule II) controlled substance because it has a high potential for abuse, but it also has accepted medical uses, such as for opioid withdrawal management.

C. C-I drugs are considered to have no accepted medical use and a high potential for abuse (e.g., heroin, LSD). Methadone is not classified as a C-I drug.

D. C-III drugs have a moderate potential for abuse and are generally used for medications like anabolic steroids or some barbiturates, but methadone is not classified under C-III.

View Question and Answer

Whether you are a student looking to ace your exams or a practicing nurse seeking to enhance your expertise , our nursing education contents will empower you with the confidence and competence to make a difference in the lives of patients and become a respected leader in the healthcare field.

Visit Naxlex, invest in your future and unlock endless possibilities with our unparalleled nursing education contents today

The nurse prepares to change a patient's medication from an intravenous to an oral form and notes that the oral form is ordered in a higher dose. The nurse understands that this is due to differences in

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

The nurse gives medication to a patient with a history of liver disease. The nurse will monitor this patient for

Correct Answer is B

Explanation

A patient is taking methadone as part of a heroin withdrawal program. The nurse understands that in this instance methadone is classified as which drug schedule?

Correct Answer is B

Explanation

When administering topical medications, which is an important nursing action?

Which drug will go through a disintegration process after it is administered?

The nurse is teaching an overweight patient to administer subcutaneous heparin. Which statement by the patient indicates understanding of the teaching?

The nurse is caring for an 80-year-old patient who has just begun taking a thiazide diuretic to treat hypertension. What is an important aspect of care for this patient?

The nurse is preparing to administer a schedule II injectable drug and is drawing up half of the contents of a single-use vial. Which nursing action is correct?

What would be the best source of drug information for a nurse?

What factors can influence drug absorption? (Select all that apply)