What factors can influence drug absorption? (Select all that apply)

Lung function

Kidney function

Liver function

Route of administration

Answer and Explanation

The Correct Answer is C

a) Lung function primarily affects gas exchange and respiratory function but does not significantly influence drug absorption.

b) Kidney function is important for drug excretion rather than absorption. It impacts drug elimination and toxicity risk rather than how well a drug is absorbed.

c) Liver function plays a key role in drug metabolism. Poor liver function can alter drug absorption and metabolism, particularly for orally administered drugs that undergo the first-pass effect.

d) The route of administration directly impacts drug absorption. For example, intravenous (IV) drugs bypass absorption entirely, while oral medications must go through the digestive system before entering circulation.

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Correct Answer is A

Explanation

A. Bioavailability refers to the proportion of a drug that enters systemic circulation and is available for therapeutic effect. Generic drugs must demonstrate bioequivalence to brand-name drugs, meaning their bioavailability must be within an acceptable range to ensure similar efficacy.

B. Critical concentration is the minimum drug level required to produce a therapeutic effect, but it is not the primary factor in generic drug substitution.

C. Distribution refers to how a drug is transported in the body after absorption, but it is not the main concern when substituting generic drugs.

D. Half-life is the time required for the drug concentration to decrease by half in the body, but it does not determine whether a generic drug can replace a brand-name drug. Bioavailability is the key factor in ensuring therapeutic equivalence.

A. Wash her hands before handling the medications. B. Consult a drug guide for compatibility. C. Question the patient concerning drug allergies.

Correct Answer is B

Explanation

A. Washing hands before handling medications is essential for infection control but is not the priority action in this scenario. Ensuring drug compatibility is crucial to prevent adverse interactions.

B. When administering two drugs simultaneously, the nurse’s priority is to determine if they are compatible, particularly for IV medications. Some medications can precipitate or cause harmful interactions when mixed, leading to reduced efficacy or adverse effects. Consulting a drug guide ensures safe administration.

C. Checking for drug allergies is important before giving any medication, but it is not the priority in this specific situation. Compatibility must be assessed first to ensure the drugs can be given together safely.

D. Identifying the patient is always necessary for safe medication administration, but in this case, ensuring drug compatibility is the first step before proceeding with administration. If the drugs are incompatible, the nurse must take alternative actions before giving them to the patient.

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What factors can influence drug absorption? (Select all that apply)

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

What concept is considered when generic drugs are substituted for brand-name drugs?

Correct Answer is A

Explanation

A nurse is caring for a patient who is supposed to receive two drugs at the same time. What is the nurse's priority action?

Correct Answer is B

Explanation

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