The nurse is educating an adult client who has been diagnosed with adrenocortical carcinoma about the prescribed mitotane 6 g P0 in divided doses. Which statement made by the client establishes the need for further clarification? a. "If I have a trauma or go into shock, the drug is temporarily stopped."

Disulfiram is a medication used to treat alcohol use disorder (AUD). It works by inhibiting the enzyme acetaldehyde dehydrogenase, which is responsible for breaking down acetaldehyde, a toxic metabolite of alcohol. When alcohol is consumed while taking disulfiram, the accumulation of acetaldehyde in the body leads to unpleasant symptoms such as flushing, sweating, nausea, and vomiting. This creates an aversive reaction to alcohol consumption, which can help the client refrain from drinking.

The aversive effects of disulfiram can last for several hours to several days after alcohol consumption, depending on the dose of disulfiram and the amount of alcohol consumed. Therefore, it is important for clients taking disulfiram to avoid all sources of alcohol, including alcoholic beverages, mouthwash, and other products containing alcohol.

It is important to note that disulfiram is not a cure for AUD, and it works best when used as part of a comprehensive treatment plan that includes counseling and support. Disulfiram should only be used under the close supervision of a healthcare provider, as it can have serious side effects if used improperly.

A: Ibuprofen does not typically interact with calcium citrate to decrease its effects. Instead, ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that can cause gastrointestinal irritation and, with long-term use, may affect kidney function.

B: Hydrochlorothiazide is a diuretic that can lead to increased calcium levels in the blood. It does not decrease the effects of calcium citrate; rather, it could potentially cause hypercalcemia if used concurrently with calcium supplements.

C: Diltiazem is a calcium channel blocker used to treat hypertension and angina. While it affects calcium channels in the heart and blood vessels, it does not typically interact with calcium citrate supplements to decrease their effectiveness.

D: Prednisone is a corticosteroid that can decrease calcium absorption and increase calcium excretion, leading to lower bone density. Long-term use of prednisone can lead to osteoporosis, making it counterproductive when taken with calcium citrate for bone health.