The nurse is caring for a client who is taking diclofenac, a nonsteroidal anti-inflammatory (NSAID) drug for rheumatoid arthritis. During a clinic visit, the client appears pale and reports increasing fatigue. Which of the client's serum laboratory values is most important for the nurse to review?

Choice A reason: This is not the most important adverse effect for the nurse to report. Nausea is a common side effect of metoclopramide, which is a prokinetic and antiemetic drug that stimulates the motility of the upper GI tract and blocks the dopamine receptors in the chemoreceptor trigger zone. Nausea may be mild or moderate, and it may subside with time or dose adjustment. The nurse should monitor the client's nausea and provide supportive measures, such as fluids, crackers, or ginger, but it is not a priority.

Choice B reason: This is the most important adverse effect for the nurse to report. Involuntary movements, or extrapyramidal symptoms, are a serious and potentially irreversible side effect of metoclopramide, which can occur due to the blockade of the dopamine receptors in the basal ganglia. Involuntary movements can include dystonia, akathisia, parkinsonism, or tardive dyskinesia, and they can affect the face, neck, limbs, or trunk. The nurse should assess the client for any signs of involuntary movements and notify the healthcare provider immediately. The nurse should also prepare to administer an anticholinergic drug, such as benztropine, to counteract the effects of metoclopramide.

Choice C reason: This is not the most important adverse effect for the nurse to report. Unusual irritability is a rare and mild side effect of metoclopramide, which may be related to the central nervous system effects of the drug. Unusual irritability may manifest as restlessness, anxiety, or agitation, and it may resolve with time or dose adjustment. The nurse should monitor the client's mood and behavior and provide reassurance and comfort, but it is not a priority.

Choice D reason: This is not the most important adverse effect for the nurse to report. Diarrhea is a rare and mild side effect of metoclopramide, which may be related to the increased motility of the GI tract. Diarrhea may be transient or self-limiting, and it may be managed with fluids, electrolytes, or antidiarrheal drugs. The nurse should monitor the client's stool frequency and consistency and provide hydration and hygiene, but it is not a priority.

Choice A reason: This is not an appropriate instruction for the nurse to include in the client's plan of care. Replacing salt with a salt substitute is not recommended for clients taking spironolactone, as most salt substitutes contain potassium. Spironolactone is a potassium-sparing diuretic that can cause hyperkalemia, or high levels of potassium in the blood. The client should avoid salt substitutes and other sources of potassium.

Choice B reason: This is not an appropriate instruction for the nurse to include in the client's plan of care. Monitoring skin for excessive bruising is not related to the use of spironolactone, as it does not affect the blood clotting process. The client should monitor for signs of bleeding, such as nosebleeds, gum bleeding, or blood in the urine or stool, if he or she is taking other medications that can interfere with clotting, such as aspirin or warfarin.

Choice C reason: This is not an appropriate instruction for the nurse to include in the client's plan of care. Covering the skin before going outside is not necessary for clients taking spironolactone, as it does not cause photosensitivity or increased risk of sunburn. The client should protect the skin from sun exposure as part of general health promotion, but it is not specific to spironolactone therapy.

Choice D reason: This is the appropriate instruction for the nurse to include in the client's plan of care. Limiting intake of high-potassium foods is important for clients taking spironolactone, as it can prevent hyperkalemia and its complications, such as cardiac arrhythmias, muscle weakness, or paralysis. The client should avoid foods that are rich in potassium, such as bananas, oranges, tomatoes, potatoes, spinach, and dairy products. The client should also have regular blood tests to monitor the potassium levels.