The hormone responsible for maturation of mammary gland tissue is:

Choice A reason: Diabetes mellitus is not a direct consequence of inadequate weight gain during pregnancy for the infant. However, maternal diabetes can increase the risk of fetal macrosomia (large birth weight), congenital anomalies, and neonatal hypoglycemia (low blood sugar) in the infant.

Choice B reason: Down syndrome is not a direct consequence of inadequate weight gain during pregnancy for the infant. Down syndrome is a genetic disorder caused by an extra copy of chromosome 21 in the cells of the fetus. The risk of having a baby with Down syndrome increases with maternal age, but it is not related to maternal weight or nutrition².

Choice C reason: Spina bifida is not a direct consequence of inadequate weight gain during pregnancy for the infant. Spina bifida is a neural tube defect that occurs when the spine and spinal cord do not form properly in the fetus. The main risk factor for spina bifida is a lack of folic acid (a B vitamin) in the mother's diet before and during pregnancy.

Choice D reason: Intrauterine growth restriction (IUGR) is a condition in which the fetus does not grow as expected and has a low birth weight. IUGR can have many causes, such as placental problems, infections, chromosomal abnormalities, and maternal factors. One of the maternal factors that can contribute to IUGR is inadequate weight gain during pregnancy, especially in underweight women. IUGR can increase the risk of complications for the infant, such as preterm birth, low Apgar score, hypothermia, hypoglycemia, and breathing problems⁵.

Choice A reason: The NST has no known contraindications, as it is a non-invasive and safe test that does not stimulate uterine contractions or cause fetal distress. It is the most widely used method of antepartum fetal surveillance.

Choice B reason: The NST is not slightly more expensive than the CST, as it requires less time and equipment. The NST usually takes 20 to 40 minutes, while the CST may take up to 2 hours. The NST only needs a fetal monitor, while the CST also needs an intravenous line and oxytocin infusion.

Choice C reason: The NST does not have fewer false-positive results than the CST, as it has a higher rate of nonreactive results that may indicate fetal compromise when there is none. A nonreactive NST is one that does not show at least two accelerations of the fetal heart rate of 15 beats per minute or more lasting 15 seconds or more in a 20-minute period.

Choice D reason: The NST is not more sensitive in detecting fetal compromise than the CST, as it has a lower predictive value for fetal well-being. A reactive NST is one that shows at least two accelerations of the fetal heart rate of 15 beats per minute or more lasting 15 seconds or more in a 20-minute period. However, a reactive NST does not rule out the possibility of fetal hypoxia or acidosis.