The antidote to warfarin toxicity is what?
Vitamin B12.
Vitamin K.
Calcium gluconate.
Protamine sulfate
The Correct Answer is B
Vitamin K is the antidote for warfarin toxicity because it can reverse the effects of warfarin by restoring the clotting factors. Warfarin is an oral anticoagulant that works by inhibiting vitamin K epoxide reductase, an enzyme that activates vitamin K in the body. Vitamin K is needed for the synthesis of active coagulation factors, such as II, VII, IX and X. By blocking vitamin K, warfarin reduces the blood’s clotting activity and prevents the formation of blood clots.
Choice A is wrong because vitamin B12 is not involved in the coagulation cascade. Vitamin B12 is mainly involved in DNA synthesis, red blood cell production and nerve function.
Choice C is wrong because calcium gluconate is not an antidote for warfarin toxicity. Calcium gluconate is used to treat low blood calcium levels or hypocalcemia. Calcium is also a cofactor for some coagulation factors, but it does not reverse the effects of warfarin.
Choice D is wrong because protamine sulfate is not an antidote for warfarin toxicity.
Protamine sulfate is used to reverse the effects of heparin, another type of anticoagulant that works by inhibiting thrombin and factor Xa.
Protamine sulfate does not affect the vitamin K-dependent coagulation factors that are inhibited by warfarin.
Normal ranges for coagulation tests that are affected by warfarin are:
• Prothrombin time (PT): 11 to 13.5 seconds
• International normalized ratio (INR): 0.8 to 1.2
• Activated partial thromboplastin time (aPTT): 25 to 35 seconds
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
Diuretics are medicines that help the kidneys get rid of excess water and salt, which can ease the symptoms of heart failure, such as breathlessness and swelling.However, diuretics may have some side effects, such as loss of potassium, which can affect the heart and require regular blood tests and dietary changes.Diuretics can also cause other electrolyte abnormalities, such as hyponatremia, hypomagnesemia, hypocalcemia, and metabolic alkalosis. Electrolyte disturbances can have serious consequences for the heart function and rhythm, as well as other organs.
Choice A is wrong because fluid retention is the opposite of what diuretics do.
Diuretics reduce fluid retention by increasing urine output and decreasing blood volume.
Choice B is wrong because hypotension is not a direct effect of diuretics on the heart, but rather a consequence of reduced blood volume and vasodilation.
Hypotension can occur with diuretic use, especially if the dose is too high or the patient is dehydrated, but it is not a specific condition caused by diuretics.
Choice C is wrong because hyperglycemia is not related to diuretics or heart failure.
Hyperglycemia is a condition of high blood sugar, which can be caused by diabetes or other factors.
Diuretics do not affect blood sugar levels directly, although some diuretics may interact with diabetes medications and affect their efficacy.
Correct Answer is C
Explanation
This is because elevating the legs can help reduce swelling and improve blood flow back to the heart by reducing the effects of gravity.Elevating the legs can also prevent blood from pooling in the veins and reduce the risk of blood clots.
Choice A is wrong because dangling the legs can increase swelling and pressure in the veins, which can worsen peripheral venous disease (PVD) symptoms and complications.
Choice B is wrong because sitting in one position for prolonged hours can impair blood circulation and increase the risk of blood clots, especially in the lower legs.People with PVD should avoid crossing their legs, wearing tight clothing, or sitting for long periods without moving.
Choice D is wrong because standing in one position can also increase swelling and pressure in the veins, which can lead to pain, ulcers, and skin changes.People with PVD should avoid standing for long periods without moving or changing positions.
Some additional information:
Peripheral venous disease (PVD) is a condition that affects blood flow in the veins and arteries outside of your heart and brain.
It can be caused by narrowing, blocking, or spasming of the blood vessels, or by blood clots in the veins.PVD can cause pain and fatigue, especially in the legs, and can lead to serious complications such as gangrene or amputation.
The most common cause of PVD is atherosclerosis, the buildup of plaque inside the artery wall.
Plaque reduces the amount of blood flow to the limbs and decreases the oxygen and nutrients available to the tissue.Other causes of PVD may include injury, infection, irregular anatomy of muscles or ligaments, or inflammation of the blood vessels.
The normal range of blood pressure in the veins is about 10 to 20 mmHg.
The normal range of oxygen saturation in the veins is about 60 to 80%.
The normal range of pulse rate in the veins is about 60 to 100 beats per minute.
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