Select the correct order in which pharmacokinetics process occur when a medication is taken via the oral route.

Distribution, Excretion, Absorption Metabolism

Absorption, Excretion, Metabolism, Distribution

Absorption, Distribution, Metabolism. Excretion

Absorption, Metabolism, Distribution, Excretion

Answer and Explanation

The Correct Answer is C

A) Distribution, Excretion, Absorption, Metabolism: This order is incorrect because absorption should occur before distribution. The medication must first be absorbed into the bloodstream before it can be distributed throughout the body. Excretion and metabolism follow after distribution, not before.

B) Absorption, Excretion, Metabolism, Distribution: This sequence is incorrect because distribution occurs after absorption and before metabolism. Excretion is the final step and occurs after metabolism.

C) Absorption, Distribution, Metabolism, Excretion: This is the correct order. After oral administration, the medication is first absorbed into the bloodstream from the gastrointestinal tract. It is then distributed throughout the body. Following distribution, the medication undergoes metabolism (primarily in the liver) to be converted into more water-soluble forms for elimination. Finally, the medication is excreted from the body, typically through the kidneys

D) Absorption, Metabolism, Distribution, Excretion: This order is incorrect because metabolism occurs after distribution, not before. After absorption, the drug must be distributed to various tissues before it is metabolized. Excretion is the final step following metabolism.

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Correct Answer is ["C","E","F"]

Explanation

A. Nitroglycerin 10mg Sublingual Tablet:
Nitroglycerin taken sublingually (under the tongue) bypasses the gastrointestinal tract and the liver’s first-pass metabolism. It is designed to act quickly and directly enter the bloodstream through the mucous membranes, avoiding significant first-pass effect.

B. Morphine 2mg IV (Intravenously):
Morphine administered intravenously bypasses the gastrointestinal tract and liver, thus avoiding the first-pass effect entirely. The drug directly enters systemic circulation, providing immediate effect.

C. Famotidine 10mg Tablet:
Famotidine, when taken orally, undergoes significant first-pass metabolism. This means that a portion of the drug is metabolized by the liver before it reaches systemic circulation, affecting its bioavailability.

D. Nitroglycerin 4mg Sublingual Tablet:
Similar to the 10mg sublingual tablet, nitroglycerin administered sublingually bypasses the first-pass effect. The medication enters the bloodstream directly through the mucous membranes in the mouth.

E. Acetaminophen 325mg Capsule:
Acetaminophen, when taken orally, undergoes first-pass metabolism. A significant portion of the drug is metabolized in the liver before reaching systemic circulation, which can impact its overall effectiveness.

F. Diphenhydramine (Benadryl) 25mg Tablet:
Diphenhydramine, taken orally, is also affected by the first-pass effect. As with other oral medications, a part of the drug is metabolized by the liver before reaching systemic circulation, which can affect its efficacy and bioavailability.

A. Category A- indicate no risk to the human fetus. B. Category C- medications indicated possible risk in humans has been reported. C. Category X - medications have reportable fetal abnormalities associated with consumption. Positive evidence of fetal risk is available in both humans and animals D. Category B -Studies indicate no risk to the animal fetus, with no information on human fetuses available.

Correct Answer is ["A","B","C","D"]

Explanation

A. Category A:
Medications classified as Category A are considered the safest during pregnancy. They have been well-studied in pregnant humans, and no risk to the fetus has been demonstrated. This classification means that adequate and well-controlled studies have shown no evidence of harm to the fetus in the first trimester and no risk in later trimesters.

B. Category C:
Category C medications have shown potential risks to the fetus in animal studies, and there are no well-controlled studies in humans. The benefits of the medication may outweigh the potential risks, but caution is advised. These medications are used when the potential benefits justify the potential risks to the fetus.

C. Category X:
Category X medications are contraindicated in pregnancy due to evidence of fetal abnormalities or risks that outweigh any potential benefits. These medications have demonstrated clear evidence of harm to the fetus in both human and animal studies, and their use is not recommended during pregnancy.

D. Category B:
Category B medications have shown no risk to animal fetuses, but there is a lack of adequate and well-controlled studies in pregnant humans. The absence of evidence of harm in animal studies suggests that these drugs are generally considered safe, though their effects on human fetuses are not well-documented.

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Select the correct order in which pharmacokinetics process occur when a medication is taken via the oral route.

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

The nurse is preparing to administer medications to a 54-year old client. Which medications taken would be affected by the first-pass effect? (Select All that Apply.)

Correct Answer is ["C","E","F"]

Explanation

Correct Answer is ["A","B","C","D"]

Explanation

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