(Select All That Apply): A nurse is educating a client about the psychosocial factors that can influence or be influenced by depression. Which of the following factors are associated with depression and its effects on cognitive processes? Select all that apply.

Choice A rationale:

Genetic theory suggests that a person's genetic makeup can predispose them to develop depression, but it does not specifically address the role of neurotransmitters in depression. While genetics can contribute to the risk of major depressive disorder (MDD), this choice doesn't focus on the neurotransmitter imbalances.

Choice B rationale:

Neuroendocrine theory pertains to the role of hormones in depression, particularly abnormalities in the hypothalamic-pituitary-adrenal (HPA) axis. While hormones play a role in mood regulation, this theory does not primarily revolve around neurotransmitter imbalances.

Choice C rationale:

Neurotransmitter theory proposes that an imbalance of neurotransmitters, such as serotonin, norepinephrine, and dopamine, contributes to the development of major depressive disorder. This theory aligns with the idea that these neurotransmitters are responsible for regulating mood, motivation, reward, cognition, and stress response.

Choice D rationale:

Environmental theory suggests that external factors, such as life events and stressors, contribute to the development of depression. While environment can indeed influence depression, it does not specifically address the neurotransmitter imbalances that are central to this question.

Choice A rationale:

Pharmacological interventions involve the use of medications to treat conditions like Major Depressive Disorder (MDD). This does not involve stimulating the brain electrically or magnetically. While antidepressant medications can have an impact on neuronal activity and neuroplasticity, they are not classified as brain stimulation therapies.

Choice B rationale:

This is the correct answer. Electroconvulsive therapy (ECT) is a treatment modality that involves passing an electrical current through the brain to induce a controlled seizure. This has been found to be effective in cases of severe depression where other treatments have not worked. Other somatic therapies might include repetitive transcranial magnetic stimulation (rTMS) and vagus nerve stimulation (VNS), both of which involve modulating brain activity through electrical or magnetic means.

Choice C rationale:

Psychotherapeutic interventions involve talking therapies aimed at addressing psychological and emotional issues. These therapies do not directly involve electrical or magnetic stimulation of the brain. While they can certainly lead to changes in neuronal activity and neuroplasticity, they are not the primary modalities for brain stimulation.

Choice D rationale:

Cognitive-behavioral therapy (CBT) is a specific type of psychotherapeutic intervention that focuses on changing thought patterns and behaviors. While CBT can lead to changes in brain activity and neuroplasticity, it does not involve direct brain stimulation through electrical or magnetic means like ECT or rTMS.