(Select All That Apply): A nurse is educating a client about the psychosocial factors that can influence or be influenced by depression. Which of the following factors are associated with depression and its effects on cognitive processes? Select all that apply.

Choice A rationale:

Symptoms of major depressive disorder (MDD) are characterized by causing significant distress, not mild distress. The distress associated with MDD is usually severe and impairs daily functioning.

Choice B rationale:

While insomnia is a common symptom of major depressive disorder (MDD), it is not necessary for the diagnosis. Other symptoms, such as changes in appetite, psychomotor agitation or retardation, fatigue, and diminished interest or pleasure, can also contribute to the diagnosis.

Choice C rationale:

The correct answer. Symptoms of major depressive disorder (MDD) must not be due to a medical condition. It's crucial to rule out medical conditions that can mimic depressive symptoms, such as hypothyroidism or certain neurological disorders.

Choice D rationale:

The presence of a manic or hypomanic episode would indicate a diagnosis of bipolar disorder, not major depressive disorder (MDD). Bipolar disorder involves distinct periods of both elevated mood and depressive episodes.

Choice E rationale:

The correct answer. To meet the diagnostic criteria for major depressive disorder (MDD) according to DSM-5, an individual must experience five or more symptoms of depression during a continuous two-week period. These symptoms must include either depressed mood or loss of interest/pleasure. The scenario did not specify all the symptoms, but the persistent feelings of sadness, guilt, worthlessness, weight loss, and insomnia described align with the criteria.

Choice A rationale:

Electroconvulsive therapy (ECT) and other somatic therapies are considered main treatment options for Major Depressive Disorder (MDD). ECT involves passing electric currents through the brain to induce controlled seizures, and it's often used in severe cases of depression that haven't responded to other treatments. Somatic therapies encompass a range of interventions that directly target the body, such as transcranial magnetic stimulation (TMS) and vagus nerve stimulation (VNS). These treatments are supported by extensive research and clinical evidence, particularly for cases where pharmacological interventions haven't been effective or suitable.

Choice B rationale:

Pharmacological interventions are indeed a mainstay in MDD treatment. However, while they are effective for many individuals, they might not work for everyone and can have side effects. Hence, the treatment approach should be tailored to the individual's needs and preferences.

Choice C rationale:

Herbal supplements are not considered main treatment options for MDD according to established clinical guidelines. While some herbal supplements might have anecdotal support for mood enhancement, their efficacy and safety are not well-established through rigorous scientific research and clinical trials.

Choice D rationale:

Physical exercise has been shown to have a positive impact on mood and can be a beneficial adjunct to MDD treatment. However, it's typically not considered a standalone main treatment option. Rather, it's often recommended as a complementary approach alongside other evidence-based treatments.

Choice E rationale:

Mindfulness-based cognitive therapy (MBCT) is a psychological approach that combines mindfulness meditation with cognitive behavioral techniques. While MBCT has shown promise in preventing relapse for individuals with recurrent depression, it's usually used as a psychotherapeutic adjunct to other main treatments like pharmacological interventions or psychotherapy.