Kidney disease can cause hypertension by:

Kidney disease can cause hypertension by activating the renin-angiotensin mechanism.
This mechanism involves the release of renin from the kidneys, which stimulates the production of angiotensin II, a hormone that constricts blood vessels and increases blood pressure.
Choice A is wrong because kidney disease does not directly signal the brain stem to increase blood pressure.
The brain stem regulates blood pressure through the autonomic nervous system, which responds to various stimuli such as stress, pain, or emotions.
Choice C is wrong because kidney disease does not increase the release (excretion) of sodium and water.
On the contrary, kidney disease can impair the ability of the kidneys to filter out excess sodium and water, which can lead to fluid retention and increased blood pressure.
Choice D is wrong because kidney disease does not stimulate the secretion of ANP.
ANP stands for atrial natriuretic peptide, a hormone that is secreted by the heart when it senses high blood pressure.
ANP causes the kidneys to excrete more sodium and water, which lowers blood pressure.

The fibrous pericardium is the loose-fitting sac around the heart that protects it and anchors it to surrounding structures.

Choice B is wrong because the epicardium is the outer layer of the heart wall, also called the visceral pericardium, and it is not a sac.
Choice C is wrong because the endocardium is the inner layer of the heart wall that forms the lining of all heart chambers, and it is not a sac.
Choice D is wrong because the visceral pericardium is another name for the epicardium, and it is not a loose-fitting sac.