A patient is receiving warfarin (Coumadin), which is 98% bound to plasma proteins. The antidepressant paroxetine (Paxil), which is 95% bound to plasma proteins, is added to the patient's daily medication. If the paroxetine displaces warfarin from its protein binding sites, which of the following will most likely to occur?
Diminished effect from warfarin
Diminished effect from paroxetine
Increased effect, and toxicity from paroxetine
Increased effect, and toxicity from warfarin
The Correct Answer is D
A. Diminished effect from warfarin: This is unlikely because displacement of warfarin from protein binding sites would increase its concentration in the bloodstream, potentially leading to increased anticoagulant effects and toxicity.
B. Diminished effect from paroxetine: This is also unlikely because displacement of paroxetine from protein binding sites would increase its concentration in the bloodstream, potentially leading to increased pharmacological effects and toxicity.
C. Increased effect, and toxicity from paroxetine: If paroxetine displaces warfarin from protein binding sites, it can increase the concentration of free warfarin in the bloodstream, leading to increased anticoagulant effects and potential toxicity.
D. Increased effect, and toxicity from warfarin: Correct. If warfarin is displaced from protein binding sites by paroxetine, it can increase the concentration of free warfarin in the bloodstream, leading to increased anticoagulant effects and potential toxicity.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is {"dropdown-group-1":"A","dropdown-group-2":"A"}
Explanation
a. Hemostasis: Hemostasis refers to the process of stopping bleeding or preventing excessive blood loss. It involves several steps, including vasoconstriction, platelet aggregation, and clot formation. Hemostasis is the correct answer because it directly addresses the stopping of blood flow to protect the body from injury.
b. Thrombolytics: Thrombolytics are medications used to dissolve blood clots. They are not the natural mechanism for stopping blood flow. Thrombolytics are not the correct answer in this context.
c. Hematopoiesis: Hematopoiesis is the process of forming blood cells (including red blood cells, white blood cells, and platelets) in the bone marrow. It is essential for maintaining blood cell populations but does not directly stop blood flow. Hematopoiesis is not related to stopping blood flow.
d. Anticoagulation: Anticoagulation refers to preventing blood clot formation. While it is important for certain medical conditions, it does not directly stop blood flow. Anticoagulation is not the primary mechanism for stopping bleeding.
Correct Answer is D
Explanation
A. Fish oil: While fish oil has some evidence for reducing inflammation, the evidence for its effectiveness in treating arthritis is mixed.
B. DHEA: DHEA is a hormone and there is not enough evidence to support its use for arthritis.
C. Garlic and soy: While garlic and soy have some general health benefits, there is no strong evidence they are effective for treating arthritis.
D. Chondroitin and glucosamine: These supplements are the most studied option for arthritis and some studies have shown they may provide modest pain relief, although the evidence is not conclusive.
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