A patient is receiving warfarin (Coumadin), which is 98% bound to plasma proteins. The antidepressant paroxetine (Paxil), which is 95% bound to plasma proteins, is added to the patient's daily medication. If the paroxetine displaces warfarin from its protein binding sites, which of the following will most likely to occur?
Diminished effect from warfarin
Diminished effect from paroxetine
Increased effect, and toxicity from paroxetine
Increased effect, and toxicity from warfarin
The Correct Answer is D
A. Diminished effect from warfarin: This is unlikely because displacement of warfarin from protein binding sites would increase its concentration in the bloodstream, potentially leading to increased anticoagulant effects and toxicity.
B. Diminished effect from paroxetine: This is also unlikely because displacement of paroxetine from protein binding sites would increase its concentration in the bloodstream, potentially leading to increased pharmacological effects and toxicity.
C. Increased effect, and toxicity from paroxetine: If paroxetine displaces warfarin from protein binding sites, it can increase the concentration of free warfarin in the bloodstream, leading to increased anticoagulant effects and potential toxicity.
D. Increased effect, and toxicity from warfarin: Correct. If warfarin is displaced from protein binding sites by paroxetine, it can increase the concentration of free warfarin in the bloodstream, leading to increased anticoagulant effects and potential toxicity.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
A. To prevent overuse of prescription medications: While some patients may use herbal therapies as an alternative to avoid overuse of prescription medications, this is not the primary reason for the widespread use of herbal therapies. People often turn to herbal remedies for their perceived natural benefits and to complement conventional treatments, rather than to prevent overuse.
B. Because herbal therapies are so much safer than manmade drugs: This is a common misconception. Herbal therapies are not necessarily safer than prescription drugs. They can have potent effects and interact with medications, potentially causing adverse reactions. The safety of herbal remedies varies widely depending on the specific herb and its use.
C. To increase feelings of wellness and promote holistic treatment: Many patients use herbal therapies as part of a holistic approach to health. They seek to improve overall wellness, balance, and harmony in their body, mind, and spirit. Herbal therapies are often integrated into a lifestyle that values natural and preventive health measures.
D. Because herbal therapies are much more regulated than prescription drugs: This statement is incorrect. Herbal therapies are generally less regulated than prescription drugs. In many countries, herbal supplements are not subject to the same rigorous testing and approval processes as prescription medications, leading to variability in quality and potency.
Correct Answer is D
Explanation
A. Easy bruising indicates the medication is effective: While some bruising is possible, excessive bruising doesn't necessarily mean the medication is working effectively. It could indicate excessive anticoagulation, requiring dose adjustments.
B. Inject the medication deep into the thigh muscle: Heparin is injected subcutaneously, targeting the fatty tissue layer just beneath the skin. Injecting into the muscle can be painful and decrease absorption.
C. Expect stools to become black and tarry: Black stools can be a sign of upper gastrointestinal bleeding, a potential but uncommon side effect. The nurse should instruct the client to report any black stools but not expect them as a normal occurrence.
D. Use a soft bristle toothbrush: This is important because heparin increases bleeding risk, and a soft-bristled toothbrush minimizes gum irritation and potential bleeding.
Whether you are a student looking to ace your exams or a practicing nurse seeking to enhance your expertise , our nursing education contents will empower you with the confidence and competence to make a difference in the lives of patients and become a respected leader in the healthcare field.
Visit Naxlex, invest in your future and unlock endless possibilities with our unparalleled nursing education contents today
Report Wrong Answer on the Current Question
Do you disagree with the answer? If yes, what is your expected answer? Explain.
Kindly be descriptive with the issue you are facing.