Choice A rationale:
While PICCs are typically intended for shorter-term use (up to 12 weeks), the fact that a PICC has been in place for 4 weeks is not, in itself, an immediate cause for concern. Regular assessment of the catheter and site is crucial, but the duration of placement alone does not warrant immediate attention.
Choice B rationale:
While it's generally recommended to change PICC dressings every 7 days, a dressing that is 3 days old is not an immediate emergency. The nurse should prioritize changing the dressing as soon as possible, but it does not require the same level of urgency as other potential complications.
Choice C rationale:
A missing securement device is a concern because it can increase the risk of catheter dislodgement or migration. However, it does not necessarily indicate an immediate threat to the patient's well-being. The nurse should promptly address the missing securement device, but it would not be the most pressing issue compared to swelling in the extremity.
Choice D rationale:
Swelling in the upper extremity where the PICC is located is a significant finding that demands immediate attention. It can be a sign of several serious complications, including:
Thrombosis: A blood clot within the vein, which can obstruct blood flow and lead to pain, swelling, and potentially more severe consequences like deep vein thrombosis (DVT) or pulmonary embolism (PE).
Infection: Inflammation and infection at the insertion site or within the bloodstream, which can cause swelling, redness, warmth, and pain. If left untreated, infection can progress to sepsis, a life-threatening condition.
Phlebitis: Inflammation of the vein, which can cause pain, redness, and swelling along the vein.
Infiltration: Leakage of fluids or medications into the surrounding tissue, leading to swelling and discomfort.
Prompt action is crucial in these cases to prevent further complications and ensure patient safety. The nurse should immediately notify the appropriate healthcare provider, initiate necessary interventions, and closely monitor the patient's condition.

Choice B rationale:
Benign tumors typically grow in the wrong place or at the wrong time. This is a key distinguishing feature of benign tumors compared to normal cells. Normal cells have precise mechanisms that control their growth, ensuring they divide and multiply only when and where they are needed. Benign tumors, however, have disruptions in these regulatory mechanisms, leading to abnormal growth patterns. This means they may grow in locations where they don't belong or continue to grow even when they are no longer needed.
Here's a detailed explanation of why the other choices are incorrect:
Choice A:
Benign tumors have not lost their cellular regulation from contact inhibition. Contact inhibition is a process that stops normal cells from growing when they come into contact with other cells. Benign tumors still maintain this ability, which helps to limit their growth and prevent them from spreading to other tissues.
Choice C:
Benign tumors do not grow through invasion of other tissue. Invasion is a hallmark feature of malignant tumors (cancers). Benign tumors, on the other hand, typically grow as encapsulated masses, meaning they are surrounded by a well-defined border that separates them from surrounding tissues. They do not infiltrate or invade surrounding structures.
Choice D:
Anaplasia refers to the loss of differentiation and resemblance to the parent cells, which is a characteristic of malignant tumors, not benign tumors. Benign tumors still maintain a degree of differentiation, meaning they retain some of the characteristics of the normal cells from which they originated.