You are instructed to administer 40 mg of methadone (Dolophine) subcutaneously for opioid detoxification. Given that you have a concentration of 30 mg/mL on hand, how much should you draw into the syringe?

Choice A rationale:

Assessing the patient's adherence to the drug regimen is the most crucial first step in this situation. Here's a comprehensive explanation:

1. Significance of Adherence in HIV Treatment:

Viral Suppression and Disease Progression: Adherence to antiretroviral therapy (ART) is paramount in HIV management. It directly impacts viral suppression, preventing disease progression, and reducing the risk of opportunistic infections and complications. Non-adherence can lead to viral rebound, increased viral load, and potential disease advancement.

Primary Cause of Treatment Failure: Suboptimal adherence is the leading cause of treatment failure in HIV patients. It can result in:

Reduced effectiveness of ART Development of drug resistance Increased healthcare costs Increased risk of transmission

2. Rationale for Prioritizing Adherence Assessment:

Direct Link to Viral Load and Health Status: A sudden decline in health status and a significant increase in viral load strongly suggest potential non-adherence. Assessing adherence early on can:

Identify the root cause of the clinical deterioration

Inform timely interventions to address adherence barriers Prevent further complications

3. Assessing Adherence Thoroughly:

Non-Judgmental Approach: Creating a supportive and non-judgmental environment is essential for honest and accurate assessment.

Open-Ended Questions: Utilize open-ended questions to explore potential challenges and barriers to adherence, such as: Difficulties with medication schedules

Side effects Financial constraints Forgetfulness

Mental health concerns Substance abuse

Lack of social support

Objective Measures: Complement patient reports with objective measures like:

Pill counts

Pharmacy refill records

Medication Event Monitoring Systems (MEMS)

4. Addressing Adherence Barriers:

Tailored Interventions: Based on the assessment findings, develop individualized strategies to enhance adherence, such as: Simplifying medication regimens

Addressing side effects

Providing medication reminders

Offering counseling and support services

Connecting patients with resources

5. Reassessing and Monitoring:

Continuous Evaluation: Regularly reassess adherence and viral load to ensure treatment effectiveness and make adjustments as needed.

Conclusion:

While other options (B, C, D) may provide valuable information, prioritizing adherence assessment is critical to promptly identify and address potential adherence issues, optimize treatment outcomes, and prevent further health decline in HIV patients experiencing viral rebound.

Step 1 is (250 mL ÷ 90 min) × 10 gtt/mL. Step 2 is 2.78 mL/min × 10 gtt/mL. Step 3 is 27.78 gtt/min. Step 4 is approximately 28 gtt/min.

Final calculated answer: 28 gtt/min.