A patient with HIV-1 has experienced a sudden decline in health status accompanied by a significant increase in viral load. What is the first action the nurse should take?

Choice A rationale:
While verifying the suitability of the solution for a central line is important, it is not the immediate next step after insertion. Solutions that are incompatible with central lines can cause damage to the catheter or precipitate in the bloodstream, leading to serious complications. However, confirming placement takes priority to ensure the line is correctly positioned before any infusion is initiated.
Choice B rationale:
Double-checking medication calculations is a crucial safety measure, but it is not the most urgent step after central line insertion. Medication administration can only occur after confirming proper placement to avoid unintended infusion into incorrect sites or tissues, potentially leading to tissue damage or ineffective treatment.
Choice D rationale:
Initiating the prescribed infusion via the new access is the desired outcome, but it cannot be done before confirming placement. Infusing medications or fluids through a misplaced line can have severe consequences, such as:
Infiltration of medications into surrounding tissues, causing inflammation, pain, and potential necrosis.
Administration of medications into unintended areas, such as the pleural space or the vasculature of the head and neck, leading to potentially life-threatening complications.
Delay in the delivery of necessary medications or fluids if the line is not positioned correctly within the central venous system.
Choice C rationale:
Confirming placement with an x-ray is the essential next step to ensure the central line is in the correct position within the central venous system. This verification is crucial for several reasons:
Prevention of complications: Misplaced central lines can cause serious complications, such as pneumothorax (collapsed lung), hemothorax (blood in the pleural space), arrhythmias (irregular heartbeats), and nerve damage.
Accurate medication and fluid delivery: Proper placement ensures that medications and fluids are delivered directly into the central circulation, allowing for rapid and effective distribution throughout the body.
Safe and effective infusion: X-ray confirmation provides visual evidence of the line's position, guiding subsequent infusion practices and reducing the risk of errors.
Early identification of malposition: If the x-ray reveals a misplaced line, adjustments can be made promptly to prevent potential complications and ensure appropriate infusion.

Choice A rationale:
Skin and mucous membranes are the most effective and crucial barriers to infection. They provide a continuous physical barrier that prevents pathogens from entering the body. Here's a detailed explanation of their protective mechanisms:
1. Physical Barrier:
Skin: The outermost layer of skin, the epidermis, is composed of tightly packed cells that are difficult for pathogens to penetrate. It's also covered in a layer of sebum, an oily substance that helps to repel water and microorganisms.
Mucous membranes: These moist linings cover the openings of the body, such as the nose, mouth, eyes, and digestive, respiratory, and urogenital tracts. They produce mucus, a sticky substance that traps pathogens and prevents them from entering the body. Mucus also contains enzymes and antibodies that can kill certain pathogens.
2. Chemical Barrier:
Skin and mucous membranes secrete a variety of substances that have antimicrobial properties. These include: Sebum: Contains fatty acids that can kill bacteria and fungi.
Sweat: Contains salt and lysozyme, an enzyme that can break down bacterial cell walls. Saliva: Contains enzymes that can break down food and kill bacteria.
Gastric acid: The highly acidic environment of the stomach kills most pathogens that are ingested.
3. Immune Barrier:
Skin and mucous membranes are home to a diverse community of microbes, known as the microbiome. These microbes play an important role in protecting against infection by competing with pathogens for resources and space.
Mucous membranes contain specialized immune cells, such as M cells and dendritic cells, that can recognize pathogens and initiate an immune response.
In contrast, the other choices are less effective barriers to infection:
Choice B: Gastrointestinal secretions, such as gastric acid, do play a role in preventing infection, but they are not as effective as skin and mucous membranes. Pathogens can still enter the body through the digestive tract, even in the presence of gastric acid.
Choice C: Colonization by host bacteria can actually help to protect against infection by competing with pathogens. However, it is not a primary barrier to infection.
Choice D: Inflammatory processes are a response to infection, not a barrier to it. They occur after pathogens have already entered the body.