A patient with HIV-1 has experienced a sudden decline in health status accompanied by a significant increase in viral load. What is the first action the nurse should take?

Choice A rationale:
Planning activities to prevent fatigue is a valid self-care strategy for SLE patients. Fatigue is a common symptom of SLE, and it can be exacerbated by overexertion. By planning activities and pacing themselves, patients can help to manage their fatigue and conserve energy.
Fatigue management strategies include:
Prioritizing tasks and delegating when possible.
Breaking down large tasks into smaller, more manageable ones. Taking frequent rest breaks throughout the day.
Maintaining a regular sleep schedule. Engaging in moderate exercise, as tolerated.
Avoiding caffeine and alcohol, which can interfere with sleep.
Addressing any underlying health conditions that may be contributing to fatigue, such as anemia or depression.
Choice B rationale:
Prioritizing rest is another essential self-care strategy for SLE patients. Rest allows the body to conserve energy and repair itself. Patients with SLE may need more rest than healthy individuals, especially during flares.
Resting strategies include:
Getting enough sleep at night. Napping during the day, as needed.
Taking breaks from activities throughout the day.
Practicing relaxation techniques, such as deep breathing or meditation.
Choice C rationale:
Sunbathing is not recommended for SLE patients, as it can trigger flares. Ultraviolet (UV) radiation from the sun can damage skin cells and exacerbate inflammation in SLE patients. This can lead to a flare-up of symptoms, such as skin rash, joint pain, and fatigue.
Sun protection strategies include:
Avoiding direct sunlight, especially during the middle of the day when UV rays are strongest. Wearing protective clothing, such as long-sleeved shirts, pants, and wide-brimmed hats.
Using sunscreen with an SPF of 30 or higher on a daily basis.
Applying sunscreen liberally and reapplying it every two hours, or more often if sweating or swimming.
Choice D rationale:
Avoiding direct sunlight is a correct self-care strategy for SLE patients.

Choice A rationale:
Skin and mucous membranes are the most effective and crucial barriers to infection. They provide a continuous physical barrier that prevents pathogens from entering the body. Here's a detailed explanation of their protective mechanisms:
1. Physical Barrier:
Skin: The outermost layer of skin, the epidermis, is composed of tightly packed cells that are difficult for pathogens to penetrate. It's also covered in a layer of sebum, an oily substance that helps to repel water and microorganisms.
Mucous membranes: These moist linings cover the openings of the body, such as the nose, mouth, eyes, and digestive, respiratory, and urogenital tracts. They produce mucus, a sticky substance that traps pathogens and prevents them from entering the body. Mucus also contains enzymes and antibodies that can kill certain pathogens.
2. Chemical Barrier:
Skin and mucous membranes secrete a variety of substances that have antimicrobial properties. These include: Sebum: Contains fatty acids that can kill bacteria and fungi.
Sweat: Contains salt and lysozyme, an enzyme that can break down bacterial cell walls. Saliva: Contains enzymes that can break down food and kill bacteria.
Gastric acid: The highly acidic environment of the stomach kills most pathogens that are ingested.
3. Immune Barrier:
Skin and mucous membranes are home to a diverse community of microbes, known as the microbiome. These microbes play an important role in protecting against infection by competing with pathogens for resources and space.
Mucous membranes contain specialized immune cells, such as M cells and dendritic cells, that can recognize pathogens and initiate an immune response.
In contrast, the other choices are less effective barriers to infection:
Choice B: Gastrointestinal secretions, such as gastric acid, do play a role in preventing infection, but they are not as effective as skin and mucous membranes. Pathogens can still enter the body through the digestive tract, even in the presence of gastric acid.
Choice C: Colonization by host bacteria can actually help to protect against infection by competing with pathogens. However, it is not a primary barrier to infection.
Choice D: Inflammatory processes are a response to infection, not a barrier to it. They occur after pathogens have already entered the body.