Choice A rationale:
While advancing age is a significant risk factor for cancer, it is not considered the single biggest risk factor. The risk of developing cancer does increase with age, primarily due to the accumulation of DNA damage over time. This damage can arise from various sources, including exposure to carcinogens, errors in DNA replication, and oxidative stress. With age, the body's ability to repair DNA damage also declines, making cells more susceptible to cancerous changes.
However, it's important to note that cancer can develop at any age, and even younger individuals can be affected if exposed to other significant risk factors.
Choice B rationale:
Exposure to tobacco is widely recognized as the single biggest risk factor for developing cancer. It is estimated to be responsible for about 25-30% of all cancer deaths worldwide.
Tobacco smoke contains over 70 known carcinogens, which are substances that can damage DNA and lead to cancer. These carcinogens can affect various organs in the body, including the lungs, mouth, throat, esophagus, stomach, pancreas, liver, bladder, kidney, cervix, and colon.
The risk of cancer increases with the amount and duration of tobacco use. Even exposure to secondhand smoke can increase the risk of cancer.
Quitting tobacco use is the most effective way to reduce the risk of cancer.
Choice C rationale:
Exposure to occupational chemicals is a known risk factor for certain types of cancer, such as lung cancer, bladder cancer, and leukemia. However, it is not considered the single biggest risk factor for developing cancer overall.
The risk of cancer from occupational chemicals depends on the specific chemical, the level of exposure, and the duration of exposure.
Workplace safety measures, such as using protective equipment and limiting exposure to hazardous chemicals, can help reduce the risk of cancer.
Choice D rationale:
Infection with certain viruses, known as oncoviruses, can increase the risk of developing certain types of cancer. For example, infection with human papillomavirus (HPV) can increase the risk of cervical cancer, and infection with hepatitis B virus (HBV) can increase the risk of liver cancer.
However, oncoviruses are not considered the single biggest risk factor for developing cancer overall. Vaccines are available to protect against some oncoviruses, such as HPV and HBV.

Choice A rationale:
Weight gain is the most objective and reliable indicator of improved nutritional status in patients with HIV-II and wasting syndrome. It directly reflects an increase in lean body mass, which is essential for restoring physical strength, immune function, and overall health.
A weight gain of 2 lb (1 kg) in a month is considered a clinically significant improvement for this patient population. It demonstrates that the patient is consuming more calories than they are expending, leading to a positive energy balance and tissue growth.
Other assessment findings, such as food intake, food choices, and oral discomfort, can be subjective and influenced by various factors, such as appetite, taste changes, nausea, fatigue, and psychosocial issues. While they provide valuable information about the patient's nutritional status, they do not directly measure the actual improvement in body composition.
Choice B rationale:
Consuming 90% of meals and snacks is a positive sign that the patient is adhering to their dietary recommendations. However, it does not guarantee that they are consuming enough calories to promote weight gain. The patient's individual energy needs and the nutritional content of the meals and snacks must be considered.
Choice C rationale:
Choosing high-protein foods is important for building and repairing tissues, but it does not ensure adequate overall caloric intake. The patient may still be experiencing a calorie deficit if they are not consuming enough total calories, even if they are focusing on protein-rich foods.
Choice D rationale:
Decreased oral discomfort can facilitate better food intake, but it does not directly reflect weight gain or improved nutritional status. The patient may still have challenges with appetite, nausea, or other factors that hinder their ability to consume enough calories.