A nurse is preparing to administer darbepoetin 0.45 mcg/kg subcutaneous once weekly to a client who weighs 198 lb. The amount available is Darbepoetin 300 mcg/mL. How many mL should the nurse administer?
(Round the answer to the nearest tenth. Use a leading zero if it applies. Do not use a trailing zero.)
The Correct Answer is ["0.1"]
To calculate the dose of darbepoetin that the nurse should administer, we can follow these steps:
Convert the client's weight from pounds to kilograms:
198 lb ÷ 2.2 = 89.82 kg (rounded to two decimal places)
Calculate the dose of darbepoetin:
0.45 mcg/kg × 89.82 kg = 40.41 mcg
Determine the volume of darbepoetin needed using the available concentration:
40.41 mcg ÷ 300 mcg/mL = 0.1347 mL
Rounding to the nearest tenth, the nurse should administer 0.1 mL of darbepoetin subcutaneously once weekly.
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Related Questions
Correct Answer is ["2.8"]
Explanation
Convert the patient's weight from pounds to kilograms:
154 lb ÷ 2.2 = 70 kg
Calculate the dose of pentamidine:
4 mg/kg × 70 kg = 280 mg
Determine the volume to be administered:
We have 100 mg/mL concentration of pentamidine.
280 mg ÷ 100 mg/mL = 2.8 mL
Therefore, the nurse should administer 2.8 mL of pentamidine to the client.
Correct Answer is A
Explanation
Choice A reason: Elimination is the process of removing a drug from the body, usually through the kidneys or the liver. Acute renal failure is a condition where the kidneys suddenly lose their ability to filter waste products and excess fluid from the blood. This can impair the elimination of drugs that are mainly excreted by the kidneys, leading to increased drug levels and potential toxicity. The nurse should monitor the patient's renal function and adjust the dose of drugs that are renally eliminated.
Choice B reason: Metabolism is the process of transforming a drug into one or more metabolites, usually by enzymes in the liver. Acute renal failure does not directly affect the metabolism of drugs, unless it causes liver damage or alters the blood flow to the liver. The nurse should monitor the patient's liver function and the levels of drugs that are metabolized by the liver.
Choice C reason: Distribution is the process of transferring a drug from the blood to the tissues and organs of the body. Acute renal failure can affect the distribution of drugs that are bound to plasma proteins, such as albumin. When the kidneys are damaged, they may leak protein into the urine, causing hypoalbuminemia (low levels of albumin in the blood). This can increase the amount of free or unbound drug in the blood, which may enhance the drug's effect or cause adverse reactions. The nurse should monitor the patient's serum albumin level and the effects of drugs that are highly protein bound.
Choice D reason: Absorption is the process of moving a drug from the site of administration to the bloodstream. Acute renal failure does not directly affect the absorption of drugs, unless it causes changes in the gastrointestinal tract, such as edema, bleeding, or motility disorders. The nurse should monitor the patient's gastrointestinal function and the bioavailability of drugs that are administered orally.
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