A nurse is planning to administer medications to a client who weighs 198 lb. The prescription reads, "filgrastim 5 mcg/kg, subcutaneous, daily." Available is filgrastim 300 mcg/mL. How many mL should the nurse plan to give with each dose? (Round the answer to the nearest tenth. Use a leading zero if it applies. Do not use a trailing zero.)

A. Dobutamine: Dobutamine is a sympathomimetic medication used to increase cardiac output in conditions such as heart failure or cardiogenic shock. It is not indicated for the management of severe hypertension.

B. Epinephrine: Epinephrine is a sympathomimetic medication used for the management of severe allergic reactions (anaphylaxis), cardiac arrest, and severe asthma exacerbations. It is not indicated for the management of severe hypertension.
C. Dexamethasone: Dexamethasone is a corticosteroid medication used for a variety of

conditions, including inflammation, allergic reactions, and certain cancers. It is not indicated for the management of severe hypertension.
D. Nitroprusside: Nitroprusside is a potent vasodilator used for the rapid reduction of blood pressure in hypertensive emergencies, such as hypertensive crises or malignant hypertension. It acts quickly to dilate both arterial and venous vessels, leading to a rapid decrease in blood pressure. Therefore, it is the appropriate choice for this client with severe hypertension and a severe headache.

A. 0.45% sodium chloride: 0.45% sodium chloride solution, also known as half-normal saline, is a hypotonic solution used for rehydration and maintenance fluid therapy. However, in cases of
major burns where there is a significant loss of fluid and electrolytes, isotonic solutions are generally preferred.
B. Lactated Ringer's: Lactated Ringer's solution is an isotonic crystalloid solution that closely resembles the electrolyte composition of extracellular fluid. It is commonly used for fluid resuscitation in clients with major burns to replace lost fluids and electrolytes and restore
intravascular volume.

C. Dextrose 5% in water: Dextrose 5% in water is a hypotonic solution used primarily for hydration in clients with normal electrolyte levels or as a vehicle for administering medications.
It is not typically used for fluid resuscitation in clients with major burns, as it does not adequately replace lost electrolytes.
D. Dextrose 5% in 0.45% sodium chloride: This solution combines dextrose 5% and 0.45% sodium chloride and is used for maintenance fluid therapy and mild dehydration. However, in cases of major burns where there is significant fluid and electrolyte loss, isotonic solutions like lactated Ringer's or normal saline are preferred for fluid resuscitation.