A nurse is explaining the pathophysiology of systemic inflammatory response syndrome (SIRS) to a group of newly licensed nurses. Which of the following statements by the nurse is accurate?

"A deregulated cytokine storm causes an inflammatory response."

"The major organ prone to injury during SIRS is the heart."

"Spleen dysfunction causes blood clotting issues."

"Activation of the inflammatory cascade causes increased perfusion."

Answer and Explanation

The Correct Answer is A

A. "A deregulated cytokine storm causes an inflammatory response": Systemic inflammatory response syndrome (SIRS) is characterized by a dysregulated inflammatory response triggered by various insults such as infection, trauma, burns, or ischemia. In SIRS, the immune system responds excessively, leading to the release of pro-inflammatory cytokines (cytokine storm), including tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6). This cytokine cascade results in widespread inflammation and systemic manifestations, such as fever, tachycardia, tachypnea, and leukocytosis.

B. "The major organ prone to injury during SIRS is the heart": While SIRS can lead to multi-organ dysfunction, including cardiac dysfunction, it does not primarily target the heart. SIRS affects multiple organs, including the lungs, kidneys, liver, and gastrointestinal tract. Cardiac dysfunction in SIRS may result from the inflammatory response, hypoperfusion, or direct myocardial injury.

C. "Spleen dysfunction causes blood clotting issues": SIRS can lead to coagulation abnormalities, but spleen dysfunction is not the primary cause. Coagulation abnormalities in SIRS are often attributed to endothelial dysfunction, activation of the coagulation cascade, and consumption of clotting factors, rather than spleen dysfunction.

D. "Activation of the inflammatory cascade causes increased perfusion": Activation of the inflammatory cascade in SIRS does not typically lead to increased perfusion. Instead, SIRS can lead to alterations in perfusion, including tissue hypoperfusion and microvascular dysfunction. In severe cases, SIRS can progress to septic shock, characterized by profound hypotension and inadequate tissue perfusion.

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Correct Answer is B

Explanation

A. Synchronized electrical cardioversion: Synchronized electrical cardioversion is a procedure used to restore normal sinus rhythm in patients with certain types of arrhythmias, such as atrial fibrillation or atrial flutter. However, it is not typically indicated for all patients with worsening heart failure and arrhythmias.

B. Cardiac resynchronization therapy (CRT): CRT, also known as biventricular pacing, involves the placement of a specialized pacemaker device to improve the coordination of contractions between the heart's chambers. It is often used in patients with heart failure and arrhythmias to help regulate the rhythm and improve cardiac function.

C. Heart catheterization with percutaneous intervention: Heart catheterization with percutaneous intervention, such as angioplasty or stent placement, is used to treat coronary artery disease by opening narrowed or blocked blood vessels. While coronary artery disease may contribute to heart failure, this procedure specifically targets the coronary arteries rather than arrhythmias.

D. Echocardiogram : An echocardiogram is a diagnostic test that uses sound waves to create images of the heart's structure and function. While an echocardiogram may provide valuable information about the heart's condition in a patient with heart failure and arrhythmias, it is not a procedure used to regulate the rhythm directly.

A. "Distributive shock occurs due to loss of myocardial contractility." B. "Distributive shock occurs due to loss of blood volume." C. "Distributive shock occurs due to systemic vasodilation." D. "Distributive shock occurs due to increased systemic vascular resistance."

Correct Answer is C

Explanation

A. "Distributive shock occurs due to loss of myocardial contractility": This statement is incorrect. Distributive shock is not primarily caused by loss of myocardial contractility. Instead, distributive shock is characterized by widespread vasodilation, which leads to inadequate tissue perfusion despite normal or high cardiac output.

B. "Distributive shock occurs due to loss of blood volume": This statement is inaccurate. Distributive shock is not primarily caused by loss of blood volume. While hypovolemia (loss of blood volume) can lead to shock, distributive shock specifically involves excessive vasodilation, resulting in a relative hypovolemia due to pooling of blood in the expanded vascular bed.

C. "Distributive shock occurs due to systemic vasodilation": This statement is correct. Distributive shock, also known as vasodilatory shock, occurs due to widespread vasodilation of the systemic vasculature. This vasodilation leads to a decrease in systemic vascular resistance, which results in the redistribution of blood flow away from vital organs and tissues, leading to inadequate tissue perfusion and shock.

D. "Distributive shock occurs due to increased systemic vascular resistance": This statement is incorrect. Distributive shock is characterized by decreased systemic vascular resistance due to vasodilation, not increased systemic vascular resistance. Increased systemic vascular resistance is more commonly associated with conditions such as hypertension or obstructive shock.

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A nurse is explaining the pathophysiology of systemic inflammatory response syndrome (SIRS) to a group of newly licensed nurses. Which of the following statements by the nurse is accurate?

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