A nurse is explaining the pathophysiology of systemic inflammatory response syndrome (SIRS) to a group of newly licensed nurses. Which of the following statements by the nurse is accurate?

"A deregulated cytokine storm causes an inflammatory response."

"The major organ prone to injury during SIRS is the heart."

"Spleen dysfunction causes blood clotting issues."

"Activation of the inflammatory cascade causes increased perfusion."

Answer and Explanation

The Correct Answer is A

A. "A deregulated cytokine storm causes an inflammatory response": Systemic inflammatory response syndrome (SIRS) is characterized by a dysregulated inflammatory response triggered by various insults such as infection, trauma, burns, or ischemia. In SIRS, the immune system responds excessively, leading to the release of pro-inflammatory cytokines (cytokine storm), including tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6). This cytokine cascade results in widespread inflammation and systemic manifestations, such as fever, tachycardia, tachypnea, and leukocytosis.

B. "The major organ prone to injury during SIRS is the heart": While SIRS can lead to multi-organ dysfunction, including cardiac dysfunction, it does not primarily target the heart. SIRS affects multiple organs, including the lungs, kidneys, liver, and gastrointestinal tract. Cardiac dysfunction in SIRS may result from the inflammatory response, hypoperfusion, or direct myocardial injury.

C. "Spleen dysfunction causes blood clotting issues": SIRS can lead to coagulation abnormalities, but spleen dysfunction is not the primary cause. Coagulation abnormalities in SIRS are often attributed to endothelial dysfunction, activation of the coagulation cascade, and consumption of clotting factors, rather than spleen dysfunction.

D. "Activation of the inflammatory cascade causes increased perfusion": Activation of the inflammatory cascade in SIRS does not typically lead to increased perfusion. Instead, SIRS can lead to alterations in perfusion, including tissue hypoperfusion and microvascular dysfunction. In severe cases, SIRS can progress to septic shock, characterized by profound hypotension and inadequate tissue perfusion.

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Correct Answer is D

Explanation

A. Creatine kinase (CK) test: While creatine kinase isoenzymes, including CK-MB, can be elevated following myocardial infarction (MI), they are not specific to cardiac muscle injury. CK is found in various tissues throughout the body, so elevated levels can also indicate damage to skeletal muscle or brain tissue, among other sources.

B. Creatine kinase-myocardial band (CK-MB) test: CK-MB is a cardiac-specific isoform of creatine kinase, and elevated levels can indicate myocardial injury, particularly in the context of an acute MI. However, troponin T is a more sensitive and specific marker for myocardial injury.

C. Brain natriuretic peptide (BNP) test: Brain natriuretic peptide is primarily used in the diagnosis and management of heart failure. While elevated BNP levels can indicate heart muscle strain or stress, they are not specific markers for acute myocardial infarction or early injury to the cardiac muscle.

D. Troponin T test: This is the correct answer. Troponin T is a highly specific marker for cardiac muscle injury. Elevated troponin levels can be detected within hours of myocardial infarction and persist for several days, making it an essential tool in the diagnosis of acute coronary syndromes, including myocardial infarction. Troponin T is considered one of the gold standard biomarkers for detecting early injury to the cardiac muscle.

A. "I can't see anything from the sides of my eyes." B. "My vision is almost gone from the center part of my eye." C. "My contact lenses just don't fit like they used to." D. "l keep seeing flashes of lights moving around in my eye."

Correct Answer is B

Explanation

A. "I can't see anything from the sides of my eyes." This statement suggests a visual field deficit, which may be indicative of conditions affecting peripheral vision, such as glaucoma, retinal detachment, or optic nerve disorders. It is not a typical symptom of cataracts.

B. "My vision is almost gone from the center part of my eye." This statement indicates a central visual impairment, which is a common symptom of cataracts. Cataracts cause clouding of the lens, leading to blurred or dimmed vision, especially in the center of the visual field. This symptom often progresses gradually over time.

C. "My contact lenses just don't fit like they used to." This statement suggests discomfort or fit issues with contact lenses and is not specifically indicative of cataracts. It may be related to changes in the shape or health of the cornea, conjunctiva, or tear film.

D. "I keep seeing flashes of lights moving around in my eye." Flashes of light in the visual field are not typical symptoms of cataracts. They may indicate other ocular conditions such as vitreous detachment, migraines with aura, or retinal disorders.

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A nurse is explaining the pathophysiology of systemic inflammatory response syndrome (SIRS) to a group of newly licensed nurses. Which of the following statements by the nurse is accurate?

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