A nurse is explaining the pathophysiology of systemic inflammatory response syndrome (SIRS) to a group of newly licensed nurses. Which of the following statements by the nurse is accurate?

"A deregulated cytokine storm causes an inflammatory response."

"The major organ prone to injury during SIRS is the heart."

"Spleen dysfunction causes blood clotting issues."

"Activation of the inflammatory cascade causes increased perfusion."

Answer and Explanation

The Correct Answer is A

A. "A deregulated cytokine storm causes an inflammatory response": Systemic inflammatory response syndrome (SIRS) is characterized by a dysregulated inflammatory response triggered by various insults such as infection, trauma, burns, or ischemia. In SIRS, the immune system responds excessively, leading to the release of pro-inflammatory cytokines (cytokine storm), including tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6). This cytokine cascade results in widespread inflammation and systemic manifestations, such as fever, tachycardia, tachypnea, and leukocytosis.

B. "The major organ prone to injury during SIRS is the heart": While SIRS can lead to multi-organ dysfunction, including cardiac dysfunction, it does not primarily target the heart. SIRS affects multiple organs, including the lungs, kidneys, liver, and gastrointestinal tract. Cardiac dysfunction in SIRS may result from the inflammatory response, hypoperfusion, or direct myocardial injury.

C. "Spleen dysfunction causes blood clotting issues": SIRS can lead to coagulation abnormalities, but spleen dysfunction is not the primary cause. Coagulation abnormalities in SIRS are often attributed to endothelial dysfunction, activation of the coagulation cascade, and consumption of clotting factors, rather than spleen dysfunction.

D. "Activation of the inflammatory cascade causes increased perfusion": Activation of the inflammatory cascade in SIRS does not typically lead to increased perfusion. Instead, SIRS can lead to alterations in perfusion, including tissue hypoperfusion and microvascular dysfunction. In severe cases, SIRS can progress to septic shock, characterized by profound hypotension and inadequate tissue perfusion.

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Correct Answer is D

Explanation

A. Stress can contribute to the development of atrial flutter, but it is not the highest risk factor compared to other options.

B. While electrolyte imbalances resulting from vomiting and diarrhea can predispose someone to arrhythmias, they are not as significant a risk factor for atrial flutter as other conditions.

C. A family history of atrial flutter may increase the likelihood of developing the condition, but it is not as significant a risk factor compared to other options.

D. A history of myocardial infarction and stent placement indicates underlying heart disease, which is a significant risk factor for developing atrial flutter. Cardiac events like myocardial infarction can lead to structural changes in the heart, such as scarring or remodeling, which can predispose individuals to atrial flutter. Therefore, this client is at the highest risk for developing atrial flutter among the options provided.

A. Diminished hair growth on the lower extremities B. Loss of pigmentation over the shin area C. Shiny appearance to the lower extremities D. Swollen and enlarged veins

Correct Answer is D

Explanation

A. Diminished hair growth on the lower extremities: Diminished hair growth on the lower extremities is not typically a manifestation of peripheral venous disease. Instead, it may suggest poor circulation or arterial insufficiency.

B. Loss of pigmentation over the shin area: Loss of pigmentation over the shin area can occur in conditions such as chronic venous insufficiency, which is a form of peripheral venous disease. However, it is not the most characteristic manifestation.

C. Shiny appearance to the lower extremities: A shiny appearance to the lower extremities is often associated with arterial insufficiency rather than peripheral venous disease. It can indicate thinning of the skin due to poor circulation and oxygenation.

D. Swollen and enlarged veins: Swollen and enlarged veins, also known as varicose veins, are classic manifestations of peripheral venous disease. These veins result from venous insufficiency, which leads to blood pooling and increased pressure in the veins, causing them to dilate and become visibly enlarged.

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A nurse is explaining the pathophysiology of systemic inflammatory response syndrome (SIRS) to a group of newly licensed nurses. Which of the following statements by the nurse is accurate?

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Naxlex Comprehensive Predictor Exams

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