A nurse is educating a client with a new prescription of alendronate (Fosamax) for osteoporosis. Which of the following statements should the nurse include in her patient's education about this medication?

A. Agitation is not a typical complication of morphine sulfate. In fact, morphine and other opioids generally cause sedation rather than agitation. Agitation may occur in rare cases due to discomfort (such as from constipation) or withdrawal symptoms, but it is not a common complication of morphine use.
B. Respiratory depression is a known and serious complication of morphine sulfate and other opioid medications. Opioids can reduce the body's respiratory drive, leading to slower and less effective breathing. This can be life-threatening, especially with higher doses or if combined with other sedative medications.
C. Dilated pupils (mydriasis) are typically not a complication of morphine use. Opioids, including morphine, typically cause constricted pupils (miosis), which is a hallmark sign of opioid use or overdose. Dilated pupils are more commonly associated with stimulant drug use (e.g., cocaine) or certain medical conditions, not opioids like morphine.
D. Bradycardia (slow heart rate) is a known side effect of morphine sulfate and other opioids. Opioids can affect the autonomic nervous system and cause a decrease in heart rate. This is particularly important to monitor for, especially in patients with existing heart conditions or those taking other medications that might also affect heart rate.
E. Diarrhea is generally not a complication of morphine use. Instead, one of the most common side effects of morphine and other opioids is constipation due to their effect on the gastrointestinal system. Opioids slow down the movement of the intestines, which can lead to constipation, but diarrhea is not a typical response.

A. Butorphanol is a mixed opioid agonist-antagonist that can cause withdrawal symptoms in opioid- dependent clients due to its partial antagonism at mu receptors.
B. Buprenorphine is a partial agonist at mu receptors and can also precipitate withdrawal symptoms in individuals who are opioid-dependent.
C. Oxycodone is a full agonist and does not cause withdrawal symptoms unless abruptly discontinued in opioid-dependent individuals.
D. Naloxone is an opioid antagonist used to reverse opioid overdose and is unlikely to cause abstinence syndrome, although it can precipitate withdrawal in opioid-dependent clients when used.