A nurse is caring for a client who is taking disulfiram for alcohol use disorder and reports ingestion of alcohol. For which of the following adverse effects should the nurse monitor?

A. "I will take the medication in the morning." - Metformin extended-release tablets are typically taken with the evening meal to minimize gastrointestinal side effects. Taking it in the morning may increase the risk of side effects during the day.
B. "I will avoid crushing this medication." - Metformin extended-release tablets should not be crushed, chewed, or broken, as doing so can disrupt the extended-release mechanism, leading to an increased risk of adverse effects or decreased efficacy.
C. "I will take the medication on an empty stomach." - While metformin can be taken with or without food, it is generally recommended to take it with meals to reduce gastrointestinal side effects. Taking it on an empty stomach may increase the risk of nausea or upset stomach.
D. "I will expect to gain weight." - Weight loss is a common side effect of metformin, particularly in individuals with type 2 diabetes. Therefore, expecting weight gain would indicate a misunderstanding of the medication's effects.

A. Hypertension:
Disulfiram does not typically cause hypertension as an adverse effect. However, consuming alcohol while taking disulfiram can lead to a range of cardiovascular effects, including hypotension rather than hypertension.

B. Headache:
Consuming alcohol while taking disulfiram can result in a severe and rapid onset of symptoms known as the disulfiram-alcohol reaction. Headache is a common symptom of this reaction, along with flushing, nausea, vomiting, and palpitations. Therefore, monitoring for headaches is essential in clients taking disulfiram who report alcohol ingestion.

C. Insomnia:
Insomnia is not a commonly reported adverse effect of disulfiram. The disulfiram-alcohol reaction primarily involves physical symptoms rather than disturbances in sleep patterns.

D. Tinnitus:
Tinnitus, or ringing in the ears, is not a typical adverse effect of disulfiram. However, disulfiram can cause a range of neurological symptoms as part of the disulfiram-alcohol reaction, but tinnitus is not commonly reported.