A nurse is caring for a client who is taking cimetidine. Which of the following client statements indicates to the nurse that the cimetidine treatment has been effective? (Select all that apply.)

When reinforcing teaching about cimetidine with a client who has peptic ulcer disease, the nurse should include the following information:

"Wait at least 1 hour after taking the medication before taking an antacid.": Cimetidine is a histamine-2 receptor antagonist that reduces stomach acid production. Taking an antacid too close in time to cimetidine may decrease its effectiveness as antacids can interfere with its absorption. The nurse should advise the client to follow the healthcare provider's instructions regarding the timing and administration of cimetidine and antacids.

The following statements are incorrect or not applicable:

"Expect breast tenderness while taking this medication.": Breast tenderness is not a common side effect of cimetidine. If the client experiences any unusual symptoms or side effects while taking the medication, they should consult their healthcare provider for further evaluation.

"Take this medication on an empty stomach.": To reduce stomach upset, this medication should be taken with food or milk

"Take ibuprofen for occasional aches and pains.": Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that can increase the risk of gastrointestinal complications, including ulcers. In individuals with peptic ulcer disease, it is generally recommended to avoid NSAIDs unless specifically prescribed by a healthcare provider. The nurse should emphasize the importance of discussing any pain management strategies or medications with the healthcare provider before use.

The manifestation of gastrointestinal perforation includes severe upper abdominal pain. This can be a significant symptom indicating a potential perforation in the gastrointestinal tract. It is important to note that gastrointestinal perforation is a medical emergency that requires immediate attention and intervention.

Hyperactive bowel sounds: This finding is more commonly associated with conditions like bowel obstruction or gastroenteritis rather than gastrointestinal perforation.

Bradycardia: Bradycardia (slower than normal heart rate) is not a typical manifestation of gastrointestinal perforation. It may be associated with other conditions or factors.

Report of epigastric fullness: Epigastric fullness can be a symptom of various gastrointestinal conditions, including peptic ulcer disease itself. However, it is not a specific manifestation of gastrointestinal perforation.