A nurse is caring for a client who has overdosed on morphine sulfate (Astramorph) and was provided naloxone (Narcan) via subcutaneous route 15 minutes ago. Which of the following signs indicate that the client has abstinence syndrome? (Select All That Apply.).

A. Agitation is not a typical complication of morphine sulfate. In fact, morphine and other opioids generally cause sedation rather than agitation. Agitation may occur in rare cases due to discomfort (such as from constipation) or withdrawal symptoms, but it is not a common complication of morphine use.
B. Respiratory depression is a known and serious complication of morphine sulfate and other opioid medications. Opioids can reduce the body's respiratory drive, leading to slower and less effective breathing. This can be life-threatening, especially with higher doses or if combined with other sedative medications.
C. Dilated pupils (mydriasis) are typically not a complication of morphine use. Opioids, including morphine, typically cause constricted pupils (miosis), which is a hallmark sign of opioid use or overdose. Dilated pupils are more commonly associated with stimulant drug use (e.g., cocaine) or certain medical conditions, not opioids like morphine.
D. Bradycardia (slow heart rate) is a known side effect of morphine sulfate and other opioids. Opioids can affect the autonomic nervous system and cause a decrease in heart rate. This is particularly important to monitor for, especially in patients with existing heart conditions or those taking other medications that might also affect heart rate.
E. Diarrhea is generally not a complication of morphine use. Instead, one of the most common side effects of morphine and other opioids is constipation due to their effect on the gastrointestinal system. Opioids slow down the movement of the intestines, which can lead to constipation, but diarrhea is not a typical response.

A. Ibuprofen does not inhibit mu receptors. Mu receptors are associated with opioid actions, while ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID).
B. While long-term use of ibuprofen may increase the risk of cardiovascular events like myocardial infarction, this is not the primary action of the drug.
C. Ibuprofen does not decrease the risk of stroke. In fact, chronic use of NSAIDs may actually increase the risk of bleeding and stroke.
D. Ibuprofen inhibits both COX-1 and COX-2 enzymes, which are involved in the inflammatory process. This inhibition helps reduce pain, inflammation, and fever.