A nurse is caring for a client who has diabetes insipidus and is receiving desmopressin by intermittent IV balus. Which of the fediowing manifestations should indicate to the nurse a therapeutic response to the medication?
Decrease in urine output
Increase in serum glucose
Increase in WBC count
Decrease in blood pressure
The Correct Answer is A
A. Decrease in urine output:
This is the correct answer. Desmopressin is a synthetic form of antidiuretic hormone (ADH) that works to reduce urine output in individuals with diabetes insipidus. A decrease in urine output indicates a positive response to the medication.
B. Increase in serum glucose:
Desmopressin does not have a direct effect on serum glucose levels. Its primary action is to increase water reabsorption in the kidneys, reducing urine output.
C. Increase in WBC count:
Desmopressin does not have a direct impact on white blood cell (WBC) count. Its main action is on fluid balance and urine concentration.
D. Decrease in blood pressure:
Desmopressin can cause a mild increase in blood pressure, particularly at higher doses. However, blood pressure changes are not the primary therapeutic effect of desmopressin in the context of diabetes insipidus.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
A. Inform the client there is a prescription available if needed:
This response does not address the urgency indicated by the prescription stating "NOW." It is essential to take immediate action when the prescription indicates an urgent administration.
B. Notify the pharmacy to send the medication immediately:
While timely medication administration is crucial, contacting the pharmacy directly without clarification from the provider may lead to misinterpretation or errors. It's important to confirm the prescription details first.
C. Administer the medication within 90 minutes:
The prescription indicating "NOW" suggests a need for more immediate administration than within 90 minutes. Waiting for 90 minutes may not be in line with the urgency implied by the prescription.
D. Contact the provider to clarify the prescription:
This is the correct action. The prescription is ambiguous, and the nurse should seek clarification from the provider regarding the urgency of administration, the reason for the medication, and any other pertinent details to ensure safe and appropriate care.

Correct Answer is C
Explanation
A. The client's absolute neutrophil count was 2.500/mm before the medication was administered:
This information does not indicate an error in the administration process. The absolute neutrophil count being 2.500/mm before the medication was given is relevant to the client's condition but does not suggest an incident related to the administration of filgrastim.
B. The nurse flushed the client's IV line with dextrose 5% in water before and after the medication was administered:
Flushing the IV line with dextrose 5% in water is a standard practice before and after medication administration. This action helps ensure that the medication is effectively delivered and that the line remains patent. There is no indication of an error in this case.
C. The medication vial sat at room temperature for 2 hr before it was administered:
Filgrastim is a medication that typically requires refrigeration to maintain stability. Allowing it to sit at room temperature for an extended period can affect its efficacy and safety. This is a deviation from the recommended storage conditions and should be reported as an incident to assess potential consequences.
D. The client had chemotherapy 12 hr before the medication was administered:
This information does not necessarily suggest an incident related to the administration of filgrastim. The timing of chemotherapy is an essential consideration in cancer treatment protocols. Filgrastim is often administered to support recovery from the hematopoietic effects of chemotherapy.
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