A nurse is preparing to administer cimetidine 300 mg IV over 15 min to a client. Available is cimetidine 300 mg/100 mL of 0.9% sodium chloride. The nurse should set the IV pump to deliver how many mL/hr?
(Round the answer to the nearest whole number. Use a leading zero if it applies. Done use a trailing zero.)

A. Weight loss:
Weight lossis not typically associated with methimazole use. In fact, hyperthyroidism (such as in Graves’ disease) can lead to unintentional weight loss due to increased metabolism. Methimazole helps normalize thyroid function, but it doesn’t directly cause weight loss.
B. Increase in pulse rate:
While an increased pulse rate is a symptom of hyperthyroidism, the goal of methimazole treatment is to normalize thyroid function and, consequently, decrease the pulse rate over time.
C. Increased sleeping:
Increased sleeping:Methimazole works by inhibiting the production of thyroid hormones (T3 and T4) in the thyroid gland. It helps normalize thyroid function by reducing excessive hormone synthesis.As thyroid hormone levels decrease due to methimazole, the client’s metabolic rate may slow down. This can lead to feelings of fatigue and increased need for rest, resulting in more sleep.
D. Warmer skin:
Warmer skin is a symptom of hyperthyroidism. With effective treatment using methimazole, the normalization of thyroid function should lead to improved thermoregulation, potentially reducing the sensation of warmer skin.

A. Absence of deep-tendon reflexes:
Absence of deep-tendon reflexes is a sign of magnesium toxicity. Magnesium sulfate, when infused in high doses, can lead to neuromuscular blockade and affect reflexes. Discontinuing the infusion and administering calcium gluconate can counteract the effects of magnesium.

B. Urine output 80 mL in 4 hours:
Urine output is not a direct indicator of magnesium toxicity. Monitoring urine output is important for assessing renal function, but it is not a specific sign of magnesium toxicity.

C. Decreased level of consciousness:
Decreased level of consciousness is another sign of magnesium toxicity. Central nervous system depression is a potential adverse effect of elevated magnesium levels. Administering calcium gluconate can help antagonize the effects of magnesium.

D. Report of chills:
Chills are not typically associated with magnesium toxicity. This symptom may indicate other issues, such as infection or discomfort.
E. Systolic blood pressure 130 mm/Hg:
Systolic blood pressure within a normal range is not a sign of magnesium toxicity. Blood pressure changes are not typically the primary indicators of magnesium toxicity.