A nurse is preparing to administer cimetidine 300 mg IV over 15 min to a client. Available is cimetidine 300 mg/100 mL of 0.9% sodium chloride. The nurse should set the IV pump to deliver how many mL/hr?
(Round the answer to the nearest whole number. Use a leading zero if it applies. Done use a trailing zero.)

A. Increased blood pressure: Heparin does not typically directly affect blood pressure. However, if there are other underlying conditions or complications related to the reason for heparin use, it might indirectly influence blood pressure. But a high aPTT level itself wouldn't directly cause an increase in blood pressure.
B. Decreased temperature: Heparin does not usually affect body temperature. Changes in temperature might occur due to other factors, but they are not directly related to heparin administration or its effects on aPTT.
C. Decreased respiratory rate: Heparin does not typically affect the respiratory rate directly. Changes in respiratory rate might occur due to other causes but are not directly correlated with heparin administration or its effects on aPTT.
D. Increased pulse rate: Heparin, especially when aPTT is elevated, might indicate that the blood is less likely to clot. An increased pulse rate could be indicative of compensatory mechanisms due to potential bleeding or changes in clotting factors influenced by heparin. It's essential to monitor for an increased pulse rate as a potential sign of bleeding complications associated with anticoagulant therapy.

A. Bradycardia:
Bradycardia is not a typical manifestation of an allergic reaction. Allergic reactions are more likely to involve symptoms such as rash, itching, swelling, and cardiovascular symptoms like tachycardia rather than bradycardia.
B. Hypotension:
This is the correct answer. Hypotension (low blood pressure) can be a sign of an allergic reaction, particularly in severe cases. Anaphylaxis, a severe allergic reaction, can lead to a rapid drop in blood pressure.
C. Polyuria:
Polyuria, excessive urine production, is not a typical manifestation of an allergic reaction. Allergic reactions are more likely to involve skin, respiratory, and cardiovascular symptoms.
D. Nausea:
Nausea can be a side effect of medications, but it is not a specific manifestation of an allergic reaction. Allergic reactions are more likely to present with symptoms such as skin rash, itching, or respiratory distress.