A nurse is assessing a client who is receiving a unit of packed red blood cells. Which of the following findings is a manifestation of acute hemolytic reaction?

Choice A reason: Bradycardia is not an adverse effect of diphenhydramine. Bradycardia is a slow heart rate, usually below 60 beats per minute. Diphenhydramine is an antihistamine that blocks the effects of histamine, a chemical that causes allergic reactions. Diphenhydramine does not affect the heart rate, although it may cause palpitations or irregular heartbeat in some cases.

Choice B reason: Constipation is an adverse effect of diphenhydramine. Constipation is a condition in which the bowel movements are infrequent, hard, or difficult to pass. Diphenhydramine has anticholinergic properties, which means it inhibits the activity of acetylcholine, a neurotransmitter that regulates the smooth muscle contraction in the gastrointestinal tract. Diphenhydramine can reduce the intestinal motility and cause constipation, as well as dry mouth, blurred vision, and urinary retention.

Choice C reason: Hypertension is not an adverse effect of diphenhydramine. Hypertension is a condition in which the blood pressure is abnormally high, usually above 140/90 mmHg. Diphenhydramine does not affect the blood pressure, although it may cause orthostatic hypotension, which is a sudden drop in blood pressure when changing positions from lying to standing. This can cause dizziness, fainting, or falls.

Choice D reason: Sedation is an adverse effect of diphenhydramine. Sedation is a state of reduced alertness, awareness, or responsiveness. Diphenhydramine can cross the blood-brain barrier and affect the central nervous system, causing drowsiness, fatigue, impaired coordination, and reduced mental performance. Diphenhydramine can also potentiate the effects of alcohol and other sedatives, such as benzodiazepines, opioids, or barbiturates. The nurse should advise the client to avoid driving, operating machinery, or performing other tasks that require attention and concentration while taking diphenhydramine.

The correct answer is: D. Apply heat to the knee.

Choice A reason:

Administering low dose aspirin is not appropriate for clients with hemophilia A because aspirin can inhibit platelet function and increase the risk of bleeding. Hemophilia A patients already have a deficiency in clotting factor VIII, and adding aspirin can exacerbate bleeding tendencies.

Choice B reason:

Preparing for an autologous blood transfusion is not a standard treatment for hemarthrosis in hemophilia A. The primary treatment involves factor replacement therapy to address the underlying clotting deficiency. Blood transfusions are generally reserved for severe cases of anemia or significant blood loss.

Choice C reason:

This action is appropriate to assess for gastrointestinal bleeding, which can be a concern in clients with hemophilia due to the risk of spontaneous bleeding. Monitoring for signs of internal bleeding is crucial.

Choice D reason:

Heat application is generally avoided in acute bleeding episodes, as it can increase blood flow and potentially worsen bleeding. Ice is preferred to reduce swelling and pain.