A client with hepatitis C has been experiencing symptoms of gastroesophageal reflux.
What H antagonist would be most appropriate for this client’s needs?
Nizatidine.
Ranitidine.
Cimetidine.
Famotidine.
The Correct Answer is D
Famotidine is a histamine type 2 receptor antagonist (H blocker) which is commonly used for treatment of acid-peptic disease and heartburn. Famotidine has been linked to rare instances of clinically apparent acute liver injury, but it is less likely to cause hepatotoxicity than cimetidine, another H blocker. Famotidine also has fewer drug interactions than cimetidine.
Choice A is wrong because nizatidine is another H blocker that can cause mild and transient serum aminotransferase elevations.
Nizatidine has not been linked to cases of clinically apparent liver injury, but it has not been widely used.
Choice B is wrong because ranitidine is another H blocker that can cause mild and transient serum aminotransferase elevations.
Ranitidine has also been associated with rare instances of clinically apparent liver injury, some of which were fatal or required liver transplantation.
Choice C is wrong because cimetidine is another H blocker that can cause mild and transient serum aminotransferase elevations.
Cimetidine has also been implicated in several cases of clinically apparent acute liver injury, some of which were severe and led to acute liver failure and death.
Cimetidine also has many drug interactions due to its inhibition of cytochrome P enzymes.
Normal ranges for serum aminotransferases are 7 to 56 U/L for alanine aminotransferase (ALT) and 10 to 40 U/L for as
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
The nurse should question an order for bismuth salts for a client with an allergy to aspirin because bismuth salts contain salicylates, which are chemically related to aspirin and can cause allergic reactions.
Choice A is wrong because rheumatoid arthritis is not a contraindication for bismuth salts.
Bismuth salts may have anti-inflammatory effects that could benefit clients with rheumatoid arthritis.
Choice B is wrong because viral gastroenteritis is not a contraindication for bismuth salts.
Bismuth salts may help reduce diarrhea and inflammation caused by viral gastroenteritis.
Choice D is wrong because hypertension is not a contraindication for bismuth salts.
Bismuth salts do not affect blood pressure or interact with antihypertensive medications.
Correct Answer is C
Explanation
The nurse should advise the client to avoid aluminum salts because they can increase the risk of aluminum toxicity when taken with sucralfate. Sucralfate forms a protective coating over the ulcer and binds to aluminum in the stomach.
Choice A is wrong because Milk of Magnesia is a magnesium-based antacid that can cause diarrhea, but does not interact with sucralfate.
Choice B is wrong because Calcium carbonate is a calcium-based antacid that can cause constipation, but does not interact with sucralfate.
Choice D is wrong because Proton pump inhibitors are drugs that reduce the production of stomach acid and can help heal ulcers.
They do not interact with sucralfate.
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