A client with hepatitis C has been experiencing symptoms of gastroesophageal reflux.
What H antagonist would be most appropriate for this client’s needs?
Nizatidine.
Ranitidine.
Cimetidine.
Famotidine.
The Correct Answer is D
Famotidine is a histamine type 2 receptor antagonist (H blocker) which is commonly used for treatment of acid-peptic disease and heartburn. Famotidine has been linked to rare instances of clinically apparent acute liver injury, but it is less likely to cause hepatotoxicity than cimetidine, another H blocker. Famotidine also has fewer drug interactions than cimetidine.
Choice A is wrong because nizatidine is another H blocker that can cause mild and transient serum aminotransferase elevations.
Nizatidine has not been linked to cases of clinically apparent liver injury, but it has not been widely used.
Choice B is wrong because ranitidine is another H blocker that can cause mild and transient serum aminotransferase elevations.
Ranitidine has also been associated with rare instances of clinically apparent liver injury, some of which were fatal or required liver transplantation.
Choice C is wrong because cimetidine is another H blocker that can cause mild and transient serum aminotransferase elevations.
Cimetidine has also been implicated in several cases of clinically apparent acute liver injury, some of which were severe and led to acute liver failure and death.
Cimetidine also has many drug interactions due to its inhibition of cytochrome P enzymes.
Normal ranges for serum aminotransferases are 7 to 56 U/L for alanine aminotransferase (ALT) and 10 to 40 U/L for as
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
The nurse should ask this question because the client is taking a chemical stimulant laxative, which can cause dehydration and electrolyte imbalance, especially in combination with medications for heart failure and osteoarthritis that may also affect fluid and electrolyte balance. The nurse should assess the client’s hydration status and risk of hypovolemia or hypotension.
Choice B. Timing of medication administration is wrong because it is not the priority question in this situation.
The nurse should ask this question later to determine if the client is taking the medications as prescribed and if there are any drug interactions or adverse effects.
Choice C. Previous effectiveness of laxatives is wrong because it is not relevant to the client’s current condition.
The nurse should ask this question later to evaluate the client’s bowel habits and history of constipation.
Choice D. The amount of fiber intake is wrong because it is not the priority question in this situation.
The nurse should ask this question later to educate the client about dietary measures to prevent constipation and promote bowel health.
Correct Answer is C
Explanation
This is an antithyroid medication that can be used safely during pregnancy, as it has a lower risk of causing birth defects or fetal hypothyroidism than other drugs. Propylthiouracil inhibits the synthesis of thyroid hormones and also blocks their conversion to the more active form.
Choice A is wrong because radioactive iodine is contraindicated during pregnancy, as it can cross the placenta and damage the fetal thyroid gland.
Radioactive iodine is used to destroy overactive thyroid cells and treat hyperthyroidism.
Choice B is wrong because alendronate is not an antithyroid medication, but a bisphosphonate that is used to treat osteoporosis and prevent bone loss.
Alendronate should not be used during pregnancy, as it may affect fetal bone development and mineralization.
Choice D is wrong because methimazole is another antithyroid medication, but it is not the drug of choice for pregnant women, as it has a higher risk of causing birth defects or fetal hypothyroidism than propylthiouracil.
Methimazole also inhibits the synthesis of thyroid hormones, but does not block their conversion to the more active form.
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