After administering propylthiouracil (PTU), what effect would the nurse anticipate the drug will have in the client’s body?
To suppress the hypothalamus’s production of thyrotropin-releasing hormone (TRH).
To suppress the anterior pituitary gland’s secretion of thyroid-stimulating hormone (TSH).
To inhibit production of thyroid hormone in the thyroid gland.
To destroy part of the thyroid gland.
The Correct Answer is C
Propylthiouracil (PTU) is an antithyroid drug that blocks the synthesis of thyroid hormones by interfering with the oxidation of iodine and the coupling of iodotyrosines.
This reduces the levels of triiodothyronine (T) and thyroxine (T) in the blood and relieves the symptoms of hyperthyroidism.
Choice A is wrong because PTU does not destroy any part of the thyroid gland.
It only inhibits the production of thyroid hormones within the gland.
Choice B is wrong because PTU does not suppress the anterior pituitary gland’s secretion of thyroid-stimulating hormone (TSH).
TSH is a hormone that stimulates the thyroid gland to produce thyroid hormones.
PTU does not affect the feedback loop between the hypothalamus, pituitary, and thyroid glands.
Choice D is wrong because PTU does not suppress the hypothalamus’s production of thyrotropin-releasing hormone (TRH).
TRH is a hormone that stimulates the pituitary gland to secrete TSH.
PTU does not affect the feedback loop between the hypothalamus, pituitary, and thyroid glands.
Normal ranges for T are 80 to 220 ng/dL, for T are 4.5 to 11.2 mcg/dL, and for TSH are 0.4 to 4.0 mIU/L.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
This is because cortisol exhibits a proper 24-h circadian rhythm that affects the cardiovascular system and other organs. Cortisol levels are normally low at the beginning of sleep and high at the moment of awakening. Taking corticosteroids at this time mimics the natural cortisol rhythm and may reduce side effects such as adrenal suppression, sleep disturbances and cardiovascular complications.
Choice A is wrong because taking corticosteroids at 08:00 may not coincide with the client’s natural cortisol peak and may cause insomnia or unpleasant dreams.
Choice B is wrong because taking corticosteroids at 22:00 may disrupt the client’s sleep quality and increase the risk of nocturnal hypertension.
Choice D is wrong because taking corticosteroids at 16:00 may interfere with the client’s natural cortisol decline and cause hyperglycemia or dyslipidemia.
Correct Answer is A
Explanation
This is because phenothiazines are contraindicated in patients with suspected or established subcortical brain damage. Phenothiazines can cause central nervous system effects such as drowsiness, dizziness, and extrapyramidal symptoms that may worsen the condition of a client with a brain injury.
Choice B is wrong because phenothiazines are not contraindicated in clients with ischemic heart disease.
However, they should be used with caution as they can cause hypotension and cardiac arrhythmias.
Choice C is wrong because phenothiazines are not contraindicated in pediatric clients.
However, they should be used with caution as they can cause sedation, anticholinergic effects, and paradoxical excitement.
Choice D is wrong because phenothiazines are not contraindicated in clients with type 2 diabetes.
However, they should be used with caution as they can cause hyperglycemia and alter the effects of antidiabetic drugs.
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