A client has prescriptions for albuterol (Proventil HFA) and salmeterol (Serevent). Which instruction should the nurse provide for this client?

A) Low-back pain:
Low-back pain is not a common manifestation of an allergic reaction to a blood transfusion. It may be associated with other conditions, such as musculoskeletal issues or renal complications, but it is not typically addressed by diphenhydramine administration during transfusion.

B) Fever:
While fever can occur as a manifestation of an adverse reaction to a blood transfusion, it is more commonly associated with non-allergic transfusion reactions such as transfusion-related acute lung injury (TRALI) or bacterial contamination of the blood product. Diphenhydramine is not specifically indicated for the prevention of fever during transfusion.

C) Dyspnea:
Dyspnea, or difficulty breathing, can occur as a manifestation of a severe allergic reaction or anaphylaxis during a blood transfusion. However, diphenhydramine alone may not be sufficient to prevent or treat severe respiratory symptoms associated with anaphylaxis. In such cases, prompt medical intervention and administration of epinephrine may be necessary. Diphenhydramine primarily targets histamine-mediated symptoms such as urticaria and itching.

D) Urticaria.
Urticaria, commonly known as hives, is a skin reaction characterized by raised, itchy welts that can occur as a result of an allergic or hypersensitivity reaction. During a blood transfusion, if the recipient's immune system reacts to foreign proteins in the transfused blood, it can lead to an allergic reaction characterized by symptoms such as urticaria, itching, flushing, and sometimes more severe reactions like anaphylaxis.
Diphenhydramine is an antihistamine medication that works by blocking the effects of histamine, a chemical released by the body during allergic reactions. By administering diphenhydramine before the blood transfusion, the nurse aims to prevent or minimize the occurrence of urticaria and other allergic symptoms.

A. Respiratory rate and pulse: Albuterol is a bronchodilator medication commonly used to relieve bronchospasm in conditions like asthma and chronic obstructive pulmonary disease (COPD). Monitoring the patient's respiratory rate and pulse is essential to assess the response to the medication and any potential adverse effects.

B. Pulse oximetry: Albuterol helps to open the airways and improve oxygenation in patients with bronchospasm. Monitoring oxygen saturation using pulse oximetry provides valuable information about the patient's respiratory status and response to treatment.

C. Capillary refill: Capillary refill is typically assessed to evaluate peripheral perfusion and circulation. While it is an important assessment in certain clinical situations, it is not directly related to monitoring the response to albuterol administration.

D. Glucose: Glucose monitoring is not typically indicated after administering albuterol nebulizer unless the patient has a history of diabetes or there are specific concerns regarding glucose levels.

E. Lung sounds: Assessing lung sounds before and after administering albuterol helps to evaluate the effectiveness of the medication in relieving bronchospasm. Improvement in lung sounds, such as decreased wheezing or clearer breath sounds, indicates a positive response to treatment.