Introduction to Acute Renal Failure
- Acute renal failure (ARF), also known as acute kidney injury (AKI), is a sudden loss of kidney function due to damage or dysfunction of the kidneys.
- It can affect anyone, but it is more common in hospitalized patients, especially those in critical care units.
- Acute renal failure is defined as a rapid decline in glomerular filtration rate (GFR), which is the rate at which the kidneys filter blood and remove waste products.
- GFR is measured by serum creatinine, which is a waste product of muscle metabolism. A normal GFR is about 90 to 120 mL/min/1.73 m2.
- ARF is diagnosed when there is an increase in serum creatinine of 0.3 mg/dL or more within 48 hours, or a decrease in urine output of less than 0.5 mL/kg/hour for 6 hours or more.
- ARF can be classified into three categories, depending on the site of the problem:
- Prerenal ARF: This occurs when there is reduced blood flow to the kidneys, resulting in decreased GFR. This can be caused by conditions such as dehydration, hypovolemia, heart failure, shock, sepsis, or renal artery stenosis.
- Intrinsic ARF: This occurs when there is damage to the kidney tissue itself, resulting in impaired filtration and tubular function. This can be caused by conditions such as acute tubular necrosis (ATN), acute interstitial nephritis (AIN), glomerulonephritis, vasculitis, or contrast-induced nephropathy.
- Postrenal ARF: This occurs when there is an obstruction to the urine flow from the kidneys, resulting in increased pressure and backflow of urine into the kidney. This can be caused by conditions such as kidney stones, benign prostatic hyperplasia (BPH), tumors, blood clots, or neurogenic bladder.
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