Etiology and Risk Factors
- The exact cause of most CHDs is unknown, but they are likely multifactorial, involving genetic, environmental, and maternal factors.
- Some genetic syndromes that are associated with CHD include Down syndrome, Turner syndrome, Marfan syndrome, DiGeorge syndrome, and Noonan syndrome.
- Some environmental factors that can increase the risk of CHD include maternal infections (rubella, cytomegalovirus, toxoplasmosis), maternal diabetes, maternal alcohol use, maternal smoking, maternal exposure to certain drugs (anticonvulsants, lithium, retinoic acid), and maternal exposure to radiation or chemicals.
- Some maternal factors that can increase the risk of CHD include advanced maternal age (>35 years), multiple gestation, preexisting cardiac disease, and history of a previous child with CHD.
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