Etiology
The most common causes of ARF vary depending on the category and the setting.
In general, prerenal ARF accounts for about 60% to 70% of cases, intrinsic ARF accounts for about 25% to 40% of cases, and postrenal ARF accounts for about 5% to 10% of cases.
Some of the specific causes of each category are:
- Prerenal ARF: Hypovolemia (due to hemorrhage, vomiting, diarrhea, burns), hypotension (due to septic shock, cardiogenic shock, anaphylactic shock), heart failure (due to myocardial infarction, arrhythmias, valvular disease), renal artery stenosis (due to atherosclerosis, fibromuscular dysplasia), hepatorenal syndrome (due to liver cirrhosis), drugs that affect renal perfusion (such as nonsteroidal anti-inflammatory drugs [NSAIDs], angiotensin-converting enzyme inhibitors [ACEIs], angiotensin receptor blockers [ARBs])
- Intrinsic ARF: Acute tubular necrosis (ATN) (due to ischemia from prerenal causes or nephrotoxins such as antibiotics [aminoglycosides], antivirals [acyclovir], antifungals [amphotericin B], chemotherapeutic agents [cisplatin], contrast media [iodinated]), acute interstitial nephritis (AIN) (due to allergic reactions to drugs such as antibiotics [penicillins], anticonvulsants [phenytoin], diuretics [furosemide], NSAIDs [ibuprofen] or infections such as streptococcal pharyngitis, cytomegalovirus [CMV], etc.), glomerulonephritis (due to immune-mediated diseases such as lupus nephritis, post-streptococcal glomerulonephritis, IgA nephropathy), vasculitis (due to systemic diseases such as granulomatosis with polyangiitis,
microscopic polyangiitis, polyarteritis nodosa), thrombotic microangiopathy (due to disorders such as hemolytic uremic syndrome [HUS], thrombotic thrombocytopenic purpura [TTP])
- Postrenal ARF: Kidney stones (due to hypercalcemia, hyperuricemia, hyperoxaluria), benign prostatic hyperplasia (BPH) (due to hormonal changes in aging men), tumors (such as bladder cancer, prostate cancer, cervical cancer), blood clots (due to trauma, surgery, anticoagulation), neurogenic bladder (due to spinal cord injury, multiple sclerosis, diabetes mellitus)
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