Which difference in pharmacokinetics does the nurse expect in the obese patient as compared with the thin patient with administration of a highly lipid-soluble drug?.

Drug distribution will be more rapid.

Drug metabolism will be incomplete.

Drug absorption will be impaired.

Drug elimination will be slowed.

Answer and Explanation

The Correct Answer is D

Answer is d. Drug elimination will be slowed. In obese patients, the elimination half-life (T1/2) of lipid-soluble drugs is increased due to their accumulation in fat stores. This leads to a slower drug elimination process.

a. Drug distribution will be more rapid: Incorrect because obesity affects drug distribution due to an increased volume of distribution (Vd) for lipid-soluble drugs. This is primarily due to the greater amount of adipose tissue in obese individuals, which serves as a reservoir for lipid-soluble drugs, leading to a larger apparent volume of distribution. However, this does not result in more rapid distribution but rather a prolonged distribution phase as the drug is distributed throughout the body.

b. Drug metabolism will be incomplete: This statement is too vague and does not directly relate to the pharmacokinetics of lipid-soluble drugs in obese patients. Drug metabolism can be affected by various factors including hepatic function, enzyme activity, and genetic polymorphisms, but the incompleteness of metabolism is not a characteristic feature of obesity.

c. Drug absorption will be impaired: Incorrect, as obesity can lead to increased absorption of oral medications due to increased gastric emptying. However, this primarily affects the absorption phase of pharmacokinetics, not elimination. In fact, increased absorption due to altered gastric emptying may result in higher initial plasma concentrations of the drug but does not directly impact its elimination rate.

d. Drug elimination will be slowed: Correct. In obese patients, the elimination of lipid-soluble drugs is slowed down due to their increased accumulation in fat stores. This is primarily attributed to the lipophilic nature of these drugs, which leads to their sequestration in adipose tissue. Consequently, the prolonged elimination half-life results in slower clearance of the drug from the body, leading to potentially prolonged pharmacological effects and increased risk of adverse reactions.

In summary, the correct answer is d because in obese patients, the pharmacokinetics of highly lipid-soluble drugs are characterized by slowed drug elimination, which is primarily due to the increased accumulation of these drugs in adipose tissue. This understanding is crucial for optimizing drug dosing and minimizing the risk of adverse effects in obese patients.

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Correct Answer is ["2"]

Explanation

The correct answer is 2 tablets. Step 1 is to divide the prescribed dose by the available dose. So, 500 mg ÷ 250 mg = 2. Rationale: The nurse needs to administer the amount of medication that will equal the prescribed dose. Since each tablet contains 250 mg of amoxicillin, two tablets will provide the 500 mg dose.

So, the correct answer is 2 tablets.

A. Checks the patient's identification band. B. Asks another nurse to identify the patient. C. Checks the name on the foot of the bed. D. Asks the roommate to verify the patient's name if the patient is confused.

Correct Answer is ["A"]

Explanation

Choice A rationale:

Checking the patient’s identification band is a standard procedure to ensure the right patient is receiving the medication.

Choice B rationale:

Asking another nurse to identify the patient is not a reliable method and could lead to errors.

Choice C rationale:

Checking the name on the foot of the bed is not a reliable method as it could be incorrect.

Choice D rationale:

Asking the roommate to verify the patient’s name is not a reliable or confidential method.

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Which difference in pharmacokinetics does the nurse expect in the obese patient as compared with the thin patient with administration of a highly lipid-soluble drug?.

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

A nurse is preparing to administer amoxicillin 500 mg PO. Available is amoxicillin 250 mg tablets. How many tablets should the nurse administer? (Round the answer to the nearest whole number. Use a leading zero if it applies. Do not use a trailing zero.)

Correct Answer is ["2"]

Explanation

The nurse is preparing to administer morning medications. Which action(s) does the nurse implement to identify the patient before administering medications? (Select all that apply).

Correct Answer is ["A"]

Explanation

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