When monitoring patients on antitubercular drug therapy, the nurse knows that which drug may cause a decrease in visual acuity?
Rifampin
Ethambutol
Streptomycin
Isoniazid
The Correct Answer is A
Choice A rationale:
Rifampin Rifampin is an antitubercular drug that is effective against all strains of Mycobacterium tuberculosis. It works by inhibiting the synthesis of RNA in the bacteria, preventing them from reproducing. However, it does not typically cause a decrease in visual acuity.
Choice B rationale:
Ethambutol Ethambutol is an antitubercular drug that can cause ocular toxicity in the form of visual field changes. It is known to induce toxic optic neuropathy, which is quite common and can lead to a decrease in visual acuity. Patients on Ethambutol therapy are advised to report any changes in visual acuity or eye discomfort immediately to their healthcare provider.
Choice C rationale:
Streptomycin Streptomycin is an aminoglycoside antibiotic used in the treatment of tuberculosis. It works by inhibiting protein synthesis in bacteria. While it can cause side effects such as ototoxicity and nephrotoxicity, it is not typically associated with a decrease in visual acuity.
Choice D rationale:
Isoniazid Isoniazid is a first-line antitubercular drug that works by inhibiting the synthesis of mycolic acids in the cell wall of Mycobacterium tuberculosis. While it can cause peripheral neuropathy, it is not typically associated with a decrease in visual acuity.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is ["2.5 "]
Explanation
Step 1: Identify the given values. The nurse needs to administer 2.5 mg of hydromorphone. The available amount is 5 mg/5 mL.
Step 2: Set up the calculation. We need to find out how many mL correspond to 2.5 mg. We can set up a proportion using the given values:
5 mL5 mg=x mL2.5 mg
Step 3: Solve for x. Cross-multiply and solve for x:
5 mg×x mL=2.5 mg×5 mL
Step 4: Simplify the equation:
x=5 mg.5 mg×5 mL
Step 5: Calculate the value of x:
x=2.5 mL
So, the nurse should administer 2.5 mL of the hydromorphone elixir.
Correct Answer is C
Explanation
Choice A rationale:
Proton pump inhibitors (PPIs) are used extensively for the treatment of gastric acid-related disorders, often over the long term, which raises the potential for clinically significant drug interactions in patients receiving concomitant medications.
However, there is no specific mention of a significant interaction between PPIs and aminoglycosides.
Choice B rationale:
Aminoglycoside antibiotics and calcium channel blockers can interact at the neuromuscular junctions. This interaction is of clinical significance because when these agents are given concurrently during the perioperative period they may lead to respiratory depression or prolonged apnea. However, this is not directly related to the therapeutic effect of aminoglycosides, but rather a side effect of their combined use.
Choice C rationale:
The loop-diuretics (ethacrynic acid, furosemide, bumetamide) and aminoglycoside antibiotics (kanamycin, gentamicin, tobramycin, amikacin, etc.) are important drugs frequently used to treat seriously ill patients. Not uncommonly both types of drugs are given to the same patient exposing that patient to the risk of a hearing loss (ototoxicity)5. In addition, the risk of ototoxicity could be enhanced by the concomitant use of loop diuretics and aminoglycoside antibiotics.
Choice D rationale:
Phenytoin is a medication used to treat seizures. It has a complex pharmacokinetic profile and can interact with many other drugs. However, there is no specific mention of a significant interaction between phenytoin and aminoglycosides.
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