Up to one-third of patients who take ACE inhibitors for hypertension report which symptom after beginning therapy?
Decreased white blood cells.
Swelling of the face and lips.
Chronic cough.
Renal failure.
The Correct Answer is C
ACE inhibitors are a type of medication used to treat high blood pressure and heart failure. They work by blocking the production of a hormone called angiotensin II, which narrows the blood vessels and increases blood pressure. By preventing this hormone from acting, ACE inhibitors lower blood pressure and reduce the workload on the heart. One of the most common side effects of ACE inhibitors is a dry cough, which occurs in 12–19% of people who take them. The cough is caused by the accumulation of a substance called bradykinin, which is normally broken down by angiotensin-converting enzyme (ACE). When ACE is inhibited, bradykinin levels increase and cause irritation and inflammation in the airways.
Choice A is wrong because decreased white blood cells are not a common side effect of ACE inhibitors.
However, some people may develop a condition called neutropenia, which is a low level of a type of white blood cell called neutrophils. This can increase the risk of infections and may require stopping the medication.
Choice B is wrong because swelling of the face and lips is not a common side effect of ACE inhibitors.
However, some people may develop a rare but serious allergic reaction called angioedema, which is a swelling of the deeper layers of the skin and mucous membranes.
This can affect the face, lips, tongue, throat, or other parts of the body and can cause difficulty breathing or swallowing. Angioedema can be life-threatening and requires immediate medical attention.
Choice D is wrong because renal failure is not a common side effect of ACE inhibitors.
However, some people may experience a decrease in kidney function or an increase in blood levels of creatinine, which is a waste product filtered by the kidneys.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Lifestyle is the greatest contributing factor that can lead to many diseases, especially noncommunicable diseases (NCDs) such as cardiovascular diseases, cancers, chronic respiratory diseases and diabetes.According to the World Health Organization (WHO), NCDs are responsible for 74% of all deaths worldwide, and they share four major risk factors: tobacco use, physical inactivity, the harmful use of alcohol and unhealthy diets.These modifiable behaviours increase the risk of metabolic risk factors such as raised blood pressure, increased blood glucose, elevated blood lipids and obesity, which can lead to NCDs.
Choice A is wrong because trauma is not a factor that can lead to many diseases, but rather a result of injuries or accidents that damage the body.Trauma can cause acute or chronic conditions, such as infections, bleeding, fractures, organ failure or post-traumatic stress disorder, but it is not a common cause of NCDs.
Choice C is wrong because congenital means present at birth or inherited.
Congenital diseases are caused by genetic mutations or environmental factors that affect the development of the fetus.
Some examples of congenital diseases are Down syndrome, cystic fibrosis, congenital heart defects and spina bifida.
Congenital diseases are not the greatest contributing factor to many diseases because they are relatively rare and often detected early.
Choice D is wrong because genetics refers to the inherited traits from parents that influence the risk of developing certain diseases.
Genetics can play a role in some NCDs, such as cancers, diabetes and some cardiovascular diseases, but it is not the only or the most important factor.
Genetics interacts with environmental and lifestyle factors to determine the likelihood of developing a disease.
Therefore, genetics alone cannot lead to many diseases.
Correct Answer is D
Explanation
Alpha 1 adrenergic blocking agents have a vasodilating effect and can be used for the management of hypertension.They work by preventing the hormone norepinephrine from tightening the muscles in the walls of smaller arteries and veins, thus lowering the blood pressure.Some examples of alpha 1 blockers are doxazosin, prazosin, and terazosin.
Choice A is wrong because alpha 3 adrenergic blockers do not exist.There are only two subtypes of alpha receptors: alpha 1 and alpha 2.
Choice B is wrong because alpha 2 adrenergic antagonists are not used for hypertension.They are used for conditions like attention deficit hyperactivity disorder (ADHD) and opioid withdrawal.Alpha 2 antagonists block the negative feedback mechanism of norepinephrine release, thus increasing the amount of norepinephrine in the blood and raising the blood pressure.
Choice C is wrong because alpha 1 adrenergic agonists have the opposite effect of alpha 1 blockers.They stimulate the alpha 1 receptors and cause vasoconstriction, which increases the blood pressure.Alpha 1 agonists are used for conditions like nasal congestion and hypotension.
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