The nurse is planning an educational program on sildenafil to a group of older male clients. Which of the following information should the nurse include in the educational program?
Consume a high-fat meal to increase the medication absorption.
Take the medication 2 hours prior to sexual activity.
Swallow the medication with grapefruit juice to improve the action.
Avoid ingestion of the medication with nitrates because it causes hypotension.
The Correct Answer is D
Choice A reason: Consuming a high-fat meal does not increase the medication absorption, but rather delays it. A high-fat meal can reduce the peak plasma concentration and prolong the onset of action of sildenafil.
Choice B reason: Taking the medication 2 hours prior to sexual activity is not the optimal timing, as sildenafil has a half-life of about 4 hours and reaches its peak effect within 30 to 120 minutes. The recommended dose is 50 mg taken as needed, approximately 1 hour before sexual activity.
Choice C reason: Swallowing the medication with grapefruit juice does not improve the action, but rather inhibits it. Grapefruit juice can interfere with the metabolism of sildenafil and increase its plasma concentration and side effects.
Choice D reason: Avoiding ingestion of the medication with nitrates is the correct information, as it can cause a severe and potentially fatal drop in blood pressure. Nitrates are drugs used to treat angina and heart failure, and they can interact with sildenafil to cause vasodilation and hypotension.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
The correct answer is a. Alcohol.
Choice A: Alcohol
Reason: Alcohol can significantly affect blood glucose levels in patients taking glimepiride. Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) can occur depending on the amount and frequency of alcohol consumption. Alcohol can enhance the blood sugar-lowering effect of glimepiride, leading to a dangerous drop in blood sugar levels, known as hypoglycemia. Symptoms of hypoglycemia include dizziness, confusion, weakness, and in severe cases, loss of consciousness. Therefore, it is advised to avoid alcohol while taking glimepiride.
Choice B: Milk
Reason: There are no known interactions between glimepiride and milk. Milk does not affect the absorption or efficacy of glimepiride. Therefore, it is generally safe to consume milk while taking this medication.
Choice C: Grapefruit juice
Reason: Grapefruit juice might theoretically increase the levels of drugs metabolized by CYP2C9, including glimepiride, due to its potential to inhibit CYP2C9 enzymes. However, this interaction has not been reported in humans and is considered unlikely to have a significant clinical impact. Therefore, grapefruit juice is not a major concern for patients taking glimepiride.
Choice D: Coffee
Reason: Coffee and other caffeinated beverages may increase blood sugar levels, which can counteract the effects of glimepiride. However, this interaction is not as significant as the interaction with alcohol. It is generally advised to monitor blood sugar levels and consume coffee in moderation while taking glimepiride.
Correct Answer is ["A","C"]
Explanation
Choice A reason: Tremors are a common sign of hypoglycemia, which occurs when the blood glucose level drops below 70 mg/dL. Hypoglycemia can cause shakiness, nervousness, and anxiety.
Choice B reason: Polydipsia, or excessive thirst, is not a manifestation of hypoglycemia, but rather of hyperglycemia, which occurs when the blood glucose level is too high. Hyperglycemia can cause dehydration, dry mouth, and increased urination.
Choice C reason: Confusion is another common sign of hypoglycemia, which can affect the brain's function and cognition. Hypoglycemia can cause dizziness, headache, difficulty concentrating, and impaired judgment.
Choice D reason: Polyphagia, or excessive hunger, is also not a manifestation of hypoglycemia, but rather of hyperglycemia. Hyperglycemia can cause the body to break down muscle and fat for energy, resulting in weight loss and increased appetite.
Choice E reason: Polyuria, or excessive urination, is also not a manifestation of hypoglycemia, but rather of hyperglycemia. Hyperglycemia can cause the kidneys to excrete excess glucose in the urine, leading to fluid loss and electrolyte imbalance.
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