The nurse is caring for a client with renal dysfunction who requires an oral antidiabetic agent.
What drug will the nurse expect to see ordered?
Tolbutamide.
Tolazamide.
Chlorpropamide.
Chlorpromazine.
The Correct Answer is A
Tolbutamide is preferred for clients with renal dysfunction, who may not be able to excrete chlorpropamide, because it is more easily cleared from the body.
Choice B. Tolazamide is wrong because it is a first-generation sulfonylurea that is used less frequently and is usually tried after tolbutamide and chlorpropamide have been shown to be ineffective.
Choice C. Chlorpropamide is wrong because it is a first-generation sulfonylurea that may accumulate in clients with renal dysfunction and cause hypoglycemia.
Choice D. Chlorpromazine is wrong because it is an antipsychotic agent, not an oral antidiabetic agent.
First-generation sulfonylureas are oral antidiabetic agents that stimulate insulin secretion from the pancreas.
They are used to treat type 2 diabetes mellitus.
The normal range of blood glucose level is 70 to 110 mg/dL.
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Naxlex Comprehensive Predictor Exams
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Correct Answer is D
Explanation
Oxygen cannot diffuse rapidly across the membrane to tissues in the eye. This is because diabetic retinopathy is a condition that occurs when high blood sugar levels damage the tiny blood vessels that nourish the retina, the light-sensitive tissue at the back of the eye. As a result, the retina becomes ischemic (lacking oxygen) and tries to grow new blood vessels that are fragile and leaky.
Choice A is wrong because inability of cells in the eye to reproduce is not a cause of diabetic retinopathy.
The retina has a high metabolic rate and needs a constant supply of oxygen and nutrients to function properly.
Choice B is wrong because increase of aqueous humor in the eye is not a cause of diabetic retinopathy.
Aqueous humor is the clear fluid that fills the front part of the eye, not the retina.
An increase of aqueous humor can cause glaucoma, which is a different eye disorder that affects the optic nerve.
Choice C is wrong because decrease of nerve innervations throughout the eye is not a cause of diabetic retinopathy.
Nerve innervations are the connections between nerves and other tissues, such as muscles or glands.
Diabetic retinopathy affects the blood vessels, not the nerves, of the retina.
Correct Answer is A
Explanation
Loratadine is a second-generation antihistamine that does not cause drowsiness or sedation as a common side effect. It can relieve the symptoms of seasonal rhinitis such as sneezing, runny nose, and itching.
Choice B. Diphenhydramine is wrong because it is a first-generation antihistamine that can cause drowsiness or sedation as a common side effect.
It can also cause dry mouth, blurred vision, and urinary retention.
Choice C. Hydroxyzine is wrong because it is also a first-generation antihistamine that can cause drowsiness or sedation as a common side effect.
It can also cause dry mouth, blurred vision, and urinary retention.
It is mainly used for anxiety and itching.
Choice D. Dexchlorphen
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