A nurse is caring for client who has sepsis and a prescription for vancomycin 1 g in 250 mL dextrose 5% (D,W) over 2 hr by IV intermittent bolus. The nurse should set the IV pump to deliver how many mL/hr? (Round the answer to the nearest whole number. Use a leading zero if it applies. Do not use a trailing zero.)

A. Yellow sclera
Yellow sclera indicates jaundice, which could be a sign of liver dysfunction. Both isoniazid and rifampin can cause hepatotoxicity, and monitoring for jaundice is crucial to ensure the safety of the client.

B. Increasing AST level
AST level is slightly elevated but remains in the upper range of normal. Continued monitoring is necessary but may not require immediate reporting unless liver function significantly deteriorates.

C. Weight loss
Weight loss is consistent with the client’s condition and does not necessarily require immediate reporting unless it is severe or unmanageable.

D. Mantoux test result
The Mantoux test result is negative, which may be expected in the early phase of tuberculosis treatment. It should be monitored over time.

E. Increasing ALT level
ALT is slightly elevated but still within normal limits, though it's essential to continue monitoring for trends.

F. Reddish-orange urine color
Reddish-orange urine is a known side effect of rifampin and does not typically require immediate reporting

A. Advise the client to place one nitroglycerin tablet under his tongue as a precaution: Nitroglycerin is contraindicated in combination with phosphodiesterase type 5 inhibitors like tadalafil due to the risk of severe hypotension. This action could worsen the client's condition.
B. Tell the client to have someone bring him to an emergency department immediately: Skin flushing is a common side effect of tadalafil and not necessarily indicative of a medical emergency, especially in the absence of chest pain or other concerning symptoms.
C. Instruct the client to increase his intake of oral fluids until the skin flushing is relieved Increasing fluid intake is not likely to alleviate the skin flushing associated with tadalafil. This response does not address the client's concern adequately.
D. Reassure the client that skin flushing is a common side effect of the medication: Tadalafil, a phosphodiesterase type 5 inhibitor, commonly causes facial flushing as a side effect. Reassuring the client about this known side effect is appropriate, especially since he is not experiencing chest pain or other concerning symptoms.