Allopurinol 115 mg/m² is prescribed to a client who weighs 55 kg and is 148 cm tall. Allopurinol is supplied in vials containing 25 mg/mL after reconstitution.
How much solution should a nurse draw for one dose?
4.6 mL
5.9 mL
66.9 mL
6.49 mL
12.4 mL
The Correct Answer is D
To find the amount of solution to draw for one dose, you need to calculate the following:
- The body surface area (BSA) of the client in square meters (m²) using the formula: BSA (m²) = √(Height (cm) x Weight (kg) / 3600)
- The dose of allopurinol in milligrams (mg) using the formula: Dose (mg) = BSA (m²) x Prescribed dose
(mg/m²)
- The volume of solution in milliliters (mL) using the formula: Volume (mL) = Dose (mg) / Concentration (mg/mL)
First, use the formula for BSA to find the client's body surface area in square meters:
BSA (m²) = √(Height (cm) x Weight (kg) / 3600)
Since the client's height is 148 cm and weight is 55 kg, plug in these values into the formula:
BSA (m²) = √(148 cm x 55 kg / 3600)
Simplify and solve for the BSA:
BSA (m²) = 1.41 m²
Next, use the formula for dose to find the amount of allopurinol in milligrams:
Dose (mg) = BSA (m²) x Prescribed dose (mg/m²)
Since the client's BSA is 1.41 m² and the prescribed dose is 115 mg/m², plug in these values into the formula:
Dose (mg) = 1.41 m² x 115 mg/m²
Simplify and solve for the dose:
Dose (mg) = 162.15 mg
Then, use the formula for volume to find the amount of solution in milliliters:
Volume (mL) = Dose (mg) / Concentration (mg/mL)
Since the dose is 162.15 mg and the concentration is 25 mg/mL, plug in these values into the formula:
Volume (mL) = 162.15 mg / 25 mg/mL
Simplify and solve for the volume:
Volume (mL) = 6.486 mL
Therefore, the nurse should draw **6.486 mL** of solution for one dose of allopurinol.

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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
To find the milliliters to administer, you need to use the formula for dosage calculation:
Volume (mL) = Dose ordered (mg) / Dose available (mg) x Volume available (mL)
Since the dose ordered is 275 mg, the dose available is 500 mg, and the volume available is 2 mL, plug in these values into the formula:
Volume (mL) = 275 mg / 500 mg x 2 mL
Simplify and solve for the volume:
Volume (mL) = 1.1 mL
Therefore, the nurse should administer **1.1 mL** of Primaxin to the patient.
Correct Answer is D
Explanation
This statement is correct because the abdomen has a large surface area and a good blood supply, which allows for a consistent and predictable absorption of insulin. Insulin is a hormone that regulates blood glucose levels and needs to be delivered in precise doses to avoid complications such as hypoglycemia (low blood glucose) or hyperglycemia (high blood glucose).
The abdomen is also easy to access and has less variation in fat thickness, which reduces the risk of injecting into the muscle or the skin instead of the subcutaneous tissue. The subcutaneous tissue is the layer of fat and connective tissue below the skin and above the muscle, where insulin injections are given.
The other statements are not correct because they do not explain why the abdomen is the preferred site for subcutaneous insulin injections or they contain false information.
a.It is the least painful location for this injection. This statement is false because pain is subjective and depends on many factors, such as the type and size of the needle, the technique and speed of injection, the temperature and viscosity of the insulin, and the individual's pain tolerance and sensitivity. The abdomen may not be the least painful location for everyone, and some people may prefer other sites, such as the arms, thighs, or butocks.
b.There are fewer insulin side effects when given in this site. This statement is false because insulin side effects are not related to the site of injection, but to the dose, type, and timing of insulin, as well as the individual's response to insulin and other factors, such as diet, exercise, stress, illness, and medications. Insulin side effects may include hypoglycemia, weight gain, allergic reactions, lipodystrophy (changes in fat tissue), or edema (swelling).
c.It causes less bruising at the site. This statement is false because bruising is caused by bleeding under the skin due to damage to blood vessels during injection. Bruising can occur at any site of injection and depends on many factors, such as the type and size of the needle, the technique and speed of injection, the pressure applied after injection, the individual's clotting ability and blood thinning medications, and the presence of any underlying conditions that affect blood vessels or circulation.

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