A patient has been given a prescription for levodopa-carbidopa for a new diagnosis of Parkinson's disease. The patient asks the nurse, "Why are there two drugs in this pill?" The nurse's best response reflects which fact?
Carbidopa prevents the breakdown of levodopa in the periphery.
Carbidopa is the biologic precursor of dopamine and can penetrate into the central nervous system.
Carbidopa allows for larger doses of levodopa to be given.
There are concerns about drug-food interactions with levodopa therapy that do not exist with the combination therapy.
The Correct Answer is A
A. Carbidopa prevents the breakdown of levodopa in the periphery, specifically in the gastrointestinal tract and peripheral tissues, allowing more levodopa to reach the brain and be converted to dopamine. This enhances the effectiveness of levodopa therapy in managing the symptoms of Parkinson's disease.
B. Carbidopa is not the biologic precursor of dopamine. It is a peripheral decarboxylase inhibitor that does not cross the blood-brain barrier.
C. Carbidopa does not directly allow for larger doses of levodopa to be given. However, by
inhibiting the peripheral breakdown of levodopa, it enhances the availability of levodopa to the central nervous system, potentially improving therapeutic efficacy.
D. While levodopa-carbidopa combination therapy may have fewer drug-food interactions compared to levodopa alone, the primary reason for combining these medications is to enhance the effectiveness of levodopa by preventing its peripheral breakdown.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is ["A","C","D","E"]
Explanation
A. Monitor the patient's respiratory rate: It's essential to monitor the patient for any adverse effects of morphine administration, particularly respiratory depression.
B. Ensure naloxone is readily available: While naloxone is an antidote for opioid overdose, administering it would depend on the patient's response and any signs of opioid toxicity, which may not be evident at this time.
C. Report the error to the facility through the proper paperwork: Reporting the medication error is crucial for documentation, investigation, and implementation of corrective actions.
D. Inform the patient's health care provider: The healthcare provider should be notified of the medication error to ensure appropriate follow-up and monitoring of the patient.
E. Document the dose of morphine given by the MedSurg nurse: Documenting the medication administration accurately is essential for the patient's medical record and continuity of care.
Correct Answer is D
Explanation
A. "Increase the dosage to twice daily.": Changing the dosage should only be done under the guidance of the prescriber based on clinical assessment, not in response to perceived lack of improvement.
B. "Take the medication on an empty stomach for improved absorption.": While taking donepezil with or without food may affect absorption, this instruction is not directly related to the timing of improvement in symptoms.
C. "It takes time for the cure to take effect.": Alzheimer's disease cannot be cured, and this statement may provide false hope to the patient's daughter.
D. "It may take up to 6 weeks to see an improvement.": This response provides accurate
information about the expected timeline for therapeutic effects of donepezil and encourages patience in observing improvement.
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