The barbiturate phenobarbital is prescribed for a patient with epilepsy. While assessing the patient's current medications, the nurse recognizes that interactions may occur with which drugs? (Select all that apply.)
Oral contraceptives
Antihistamines
Warfarin
Opioids
Diuretics
Correct Answer : A,D,E
A. Oral contraceptives: Phenobarbital can decrease the effectiveness of oral contraceptives, increasing the risk of contraceptive failure and unintended pregnancy.
B. Antihistamines: While phenobarbital can induce hepatic enzymes, leading to increased
metabolism of some antihistamines, this interaction is less clinically significant compared to the interactions with oral contraceptives, opioids, and diuretics.
C. Warfarin: Phenobarbital can induce the metabolism of warfarin, potentially reducing its anticoagulant effects and necessitating closer monitoring of international normalized ratio (INR) levels.
D. Opioids: Phenobarbital can increase the metabolism of opioids, leading to reduced analgesic effects and potentially causing inadequate pain control.
E. Diuretics: Phenobarbital can accelerate the metabolism of diuretics, potentially reducing their efficacy and necessitating adjustments in dosage or monitoring of electrolyte levels.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is ["A","C","E"]
Explanation
A. Attention deficit hyperactivity disorder (ADHD) - Correct. CNS stimulants like
methylphenidate and amphetamine derivatives are commonly used to treat ADHD by improving attention, focus, and impulse control.
B. Panic attacks - Incorrect. CNS stimulants are not typically used to treat panic attacks.
Medications such as benzodiazepines or selective serotonin reuptake inhibitors (SSRIs) are more commonly used for panic disorder.
C. Narcolepsy - Correct. CNS stimulants are used to treat narcolepsy, a sleep disorder characterized by excessive daytime sleepiness and sudden attacks of sleep.
D. Neonatal apnea - Incorrect. CNS stimulants are not indicated for neonatal apnea.
Management of neonatal apnea usually involves supportive measures, respiratory support, and caffeine citrate as a respiratory stimulant.
E. Obesity - Correct. CNS stimulants like phentermine are sometimes used as adjuncts to diet and exercise for short-term management of obesity
Correct Answer is ["0.6"]
Explanation
To find out how many milliliters (mL) of methylnaltrexone should be administered to achieve a dose of 12 mg, we need to set up a proportion based on the available concentration.
Given:
- Methylnaltrexone concentration: 8 mg per 0.4 mL
- Desired dose: 12 mg
We can set up the proportion as follows:
8 /0.4 = 12 / x
Where ( x ) is the unknown amount of methylnaltrexone in milliliters.
To solve for ( x ), we can cross multiply and then divide:
8x = 0.4 12
8x = 4.8
x = 4.8/8
x = 0.6
Therefore, the nurse should administer 0.6 mL of methylnaltrexone.
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