A nursing instructor is teaching a group of nursing students about antihistamines. Which statement by a student indicates an understanding of the mechanism of action of the antihistamines?
"Antihistamines block release of histamine from mast cells and basophils."
"Antihistamines block H1 receptors to prevent actions of histamine at these sites."
"H1 antagonists can bind to H1 receptors, H2 receptors, and muscarinic receptors."
"First-generation antihistamines are more selective than second-generation antihistamines."
The Correct Answer is B
Antihistamines primarily work by blocking the H1 receptors, which are the receptors responsible for mediating the actions of histamine in the body. By blocking these receptors, antihistamines prevent or reduce the effects of histamine, such as itching, sneezing, runny nose, and watery eyes. This is the main mechanism by which antihistamines provide their therapeutic effects. "Antihistamines block release of histamine from mast cells and basophils." This statement is incorrect. Antihistamines do not block the release of histamine; instead, they block the histamine receptors to prevent the effects of histamine.
"H1 antagonists can bind to H1 receptors, H2 receptors, and muscarinic receptors." This statement is incorrect. H1 antagonists, or H1 receptor blockers, specifically bind to H1 receptors and do not have significant affinity for H2 receptors or muscarinic receptors. "First-generation antihistamines are more selective than second-generation antihistamines." This statement is incorrect. First-generation antihistamines are generally less selective and can have more sedating and anticholinergic effects compared to second-generation antihistamines, which are designed to be more selective for H1 receptors and have reduced sedative properties.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of medications commonly used to relieve pain, reduce inflammation, and lower fever. They work by inhibiting the production of prostaglandins, which are substances in the body that play a role in pain and inflammation. Celecoxib specifically belongs to the subclass of NSAIDs known as selective COX-2 inhibitors, which target the enzyme cyclooxygenase-2 (COX-2). By selectively inhibiting COX-2, celecoxib helps to reduce inflammation and pain while potentially minimizing the gastrointestinal side effects associated with traditional non-selective NSAIDs.
Correct Answer is A
Explanation
Effective teaching for a patient with peptic ulcer disease focuses on promoting understanding and adherence to the treatment plan, as well as addressing lifestyle modifications that can help manage the condition. Stress reduction is an important aspect of ulcer management, as stress
can exacerbate symptoms and delay healing. If the patient acknowledges learning relaxation strategies that decrease their stress, it indicates that they have grasped the concept and are likely to implement it in their daily life.
It is crucial for the patient to understand that any potential side effects should be reported to the healthcare provider, who will then determine the appropriate course of action. Abruptly stopping medications without medical guidance can have adverse consequences. While pain relief is an important goal, the treatment for peptic ulcer disease typically involves addressing the underlying cause, such as Helicobacter pylori infection or reducing stomach acid production. The patient should follow the treatment regimen as prescribed by the healthcare provider, even if they experience pain relief, to ensure proper healing and prevent ulcer recurrence.
Different antacids have different formulations and ingredients, and they may vary in terms of effectiveness and duration of action. It is important for the patient to consult with their healthcare provider or pharmacist to determine which antacid is most suitable for their specific needs.
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