A nurse who is caring for a preschooler should question a prescription for which of the following antibiotics?

The nurse should identify a history of asthma as a contraindication for the administration of verapamil. Verapamil is a calcium channel blocker commonly used to treat high blood pressure, angina, and certain heart rhythm disorders. However, it can cause bronchospasm and worsen symptoms in individuals with asthma or other reactive airway diseases. Therefore, verapamil should be avoided in clients with a history of asthma.

History of heart failure (B) is not a contraindication for verapamil use. In fact, verapamil is sometimes prescribed for certain types of heart failure. However, caution is required and careful monitoring is necessary in clients with heart failure.

Systolic blood pressure of 110 mm Hg (C) is not a contraindication for verapamil. Verapamil is often prescribed to lower blood pressure. However, it may require dose adjustments based on the client's blood pressure response.

Blood creatinine level of 1.0 mg/dL (D) is within the normal range and does not pose a contraindication for verapamil use.

Neonatal abstinence syndrome (NAS) is a group of withdrawal symptoms that occur in newborns who were exposed to drugs, including heroin, in utero. Hyporeflexia, which refers to reduced or diminished reflexes, is one of the key findings in neonates experiencing NAS.

During pregnancy, when the mother uses opioids like heroin, the baby becomes dependent on the drug. After birth, when the drug is no longer available, the baby experiences withdrawal symptoms as the body adjusts to the absence of the drug. Hyporeflexia is a common manifestation of NAS and is observed due to the central nervous system's response to the withdrawal.

Let's go through the other options:

B. Frequent yawning: While yawning can be seen in neonates with NAS, it is not as specific to the condition as hyporeflexia. Yawning can occur for various reasons and may not always be indicative of NAS.

C. Respiratory depression: Respiratory depression can be a severe complication of opioid exposure in utero and can result in life-threatening situations for the neonate. However, it is not specific to NAS. Respiratory depression is more closely associated with opioid overdose in the newborn, which can be a separate concern from NAS.

D. Constipation: Constipation is a possible symptom in neonates experiencing NAS, but it is not as specific as hyporeflexia. Constipation can occur due to various factors and is not unique to NAS.