A nurse is reviewing the medical record of a client who is taking epoetin alfa. Which of the following laboratory tests should the nurse monitor to determine the effectiveness of the medication? (Select all that apply.)

A. Hemoglobin level: The hemoglobin level measures the amount of hemoglobin, the oxygen-carrying protein in red blood cells, in the blood. Warfarin is not directly responsible for increasing or decreasing the hemoglobin level. While warfarin can lead to bleeding complications in some cases, it does not specifically target the hemoglobin level, so it is not a direct indicator of the medication's effectiveness.

B. Platelet count: The platelet count measures the number of platelets in the blood, which are essential for blood clotting. Warfarin does not directly affect platelet production or count. It works by inhibiting the production of certain clotting factors, not by affecting platelets. Monitoring the platelet count is important, but it is not an indicator of warfarin's effectiveness in preventing excessive clotting.

C. Prothrombin time (PT) or activated partial thromboplastin time (aPTT): Prothrombin time (PT) and activated partial thromboplastin time (aPTT) are coagulation tests used to assess different types of anticoagulant medications, such as heparin. Warfarin's effect is measured using the International Normalized Ratio (INR). PT and aPTT are not specific to warfarin therapy and are not used to monitor its effectiveness. The INR is the appropriate laboratory test for assessing the efficacy of warfarin therapy.

D. International Normalized Ratio (INR): This is the correct answer. The International Normalized Ratio (INR) is the laboratory test used to monitor the effectiveness of warfarin therapy. The INR measures the time it takes for the blood to clot and reflects the anticoagulant effect of warfarin. A therapeutic INR within the target range (e.g., INR = 2.0 to 3.0 for most indications) indicates that warfarin has been effective in preventing excessive clotting and reducing the risk of complications associated with blood clots.

To calculate the rate at which the IV pump should be set to deliver dopamine, we need to determine the total amount of dopamine in the infusion and divide it by the desired dose per minute.

Given:

Dopamine concentration: 400 mg in 250 mL

Desired dose: 5 mcg/kg/min

Patient weight: 220 lb

First, we need to convert the patient's weight from pounds to kilograms:

220 lb ÷ 2.2 = 100 kg

Next, we need to calculate the total amount of dopamine needed per minute:

5 mcg/kg/min × 100 kg = 500 mcg/min

Now, we need to convert the dopamine dose from mcg to mg:

500 mcg/min ÷ 1000 = 0.5 mg/min

To determine the infusion rate in mL/hr, we divide the dose in mg/min by the dopamine concentration in the infusion solution:

0.5 mg/min ÷ 250 mL = 0.002 mL/min

Finally, we convert the infusion rate from mL/min to mL/hr by multiplying by 60:

0.002 mL/min × 60 min = 0.12 mL/hr

Therefore, the nurse should set the IV pump to deliver 0.12 mL/hr.