A nurse needs to infuse esmolol to a patient weighing 65 kg. The dose on hand is 2,500 mg esmolol in 250 mL of fluid. The patient requires a dose of 200 mcg/kg/min to control a hypertensive crisis. Which rate should the nurse calculate to infuse this medication? Round to the nearest whole number.

To find the milliliters per dose, you need to use the formula for dosage calculation:

Volume (mL) = Dose ordered (mg) / Concentration (mg/mL) x Volume available (mL)

Since the dose ordered is 0.5 grams, the concentration is 125 mg/5 mL, and the volume available is 5 mL, plug in these values into the formula:

Volume (mL) = 0.5 grams / 125 mg/5 mL x 5 mL

However, before you can simplify and solve for the volume, you need to convert the dose from grams to milligrams by multiplying by 1000:

Volume (mL) = 500 mg / 125 mg/5 mL x 5 m

Simplify and solve for the volume:

Volume (mL) = 20 mL

Therefore, the nurse should administer **20 mL** of Amoxil per dose to the patient.

To find the answer, we need to convert the units of the medication order and the infusion rate to the same units. We can use the following conversions:

1 mcg = 0.001 mg 1 kg = 1000 g 1 min = 60 s 1 h = 3600 s

The medication order is 140 mcg/kg/min, which means the patient needs 140 mcg of medication per kilogram of body weight per minute. The patient weighs 60 kg, so we multiply 140 mcg by 60 kg to get the total amount of medication per minute:

140 mcg/kg/min x 60 kg = 8400 mcg/min

We then convert this to milligrams by dividing by 1000:

8400 mcg/min / 1000 = 8.4 mg/min

The infusion rate is 10 mL/h, which means the patient receives 10 mL of fluid per hour. We convert this to minutes by dividing by 60:

10 mL/h / 60 = 0.167 mL/min

We can now find the concentration of the medication in the fluid by dividing the amount of medication per minute by the amount of fluid per minute:

8.4 mg/min / 0.167 mL/min = 50.3 mg/mL

This means that for every milliliter of fluid, there are 50.3 milligrams of medication. To find how many milligrams of medication are in one hour, we multiply the concentration by the infusion rate:

50.3 mg/mL x 10 mL/h = 503 mg/h

This is the total amount of medication that the patient receives in one hour. To find how many milligrams are in one dose, we divide this by the number of doses per hour, which is one:

503 mg/h / 1 dose/h = 503 mg/dose

This is the final answer, but we need to round it to the nearest tenth, as per the instructions: 503 mg/dose ≈ 67.2 mg/dose