A nurse is teaching a client who is to undergo placement of a nontunneled percutaneous central venous access device. Which of the following statements should the nurse include in the teaching?

Choice A reason: Advising over-the-counter medications as safe is incorrect, as many, like NSAIDs, increase warfarin’s bleeding risk by inhibiting platelets or affecting liver metabolism. Warfarin’s narrow therapeutic index requires careful management to prevent hemorrhage, making broad safety claims dangerous without specific evaluation.
Choice B reason: Consulting the pharmacist identifies interactions with warfarin, a vitamin K antagonist metabolized by CYP450 enzymes. Many drugs alter warfarin’s efficacy, risking thrombosis or bleeding. Pharmacist expertise ensures safe polypharmacy, maintaining therapeutic INR levels critical for managing pulmonary emboli effectively.
Choice C reason: Recommending warfarin with other medications ignores interaction risks and timing needs. Warfarin’s absorption is unaffected by timing, but CYP450 interactions can alter INR. This advice is irrelevant to safety, missing the need for individualized regimen assessment to prevent complications in anticoagulation therapy.
Choice D reason: Cranberry juice may enhance warfarin’s effect by inhibiting CYP2C9, increasing INR and bleeding risk. Advising its use without monitoring is unsafe, as dietary factors can destabilize anticoagulation, potentially causing hemorrhage in clients with pulmonary emboli, requiring careful dietary guidance.

Choice A reason: A quiet environment reduces sensory stimulation, which can elevate intracranial pressure (ICP) by increasing cerebral blood flow. Minimizing noise helps stabilize intracranial dynamics, preventing exacerbation of brain injury. This intervention supports neurological stability, critical in traumatic brain injury management to avoid secondary damage.
Choice B reason: Monitoring vital signs every 8 hours is inadequate for increased ICP, which requires frequent checks (e.g., every 1-2 hours). Changes in blood pressure or respiration signal worsening ICP, risking herniation. Infrequent monitoring delays detection of neurological deterioration, compromising timely intervention in brain injury.
Choice C reason: Coughing and deep breathing increase intrathoracic pressure, elevating ICP by impeding cerebral venous return. This is contraindicated in traumatic brain injury, as it risks worsening cerebral edema or causing herniation, potentially leading to severe neurological damage or fatal outcomes in affected clients.
Choice D reason: A 30-degree head-of-bed elevation promotes cerebral venous drainage, reducing ICP. This position optimizes cerebral perfusion pressure, minimizing venous congestion in traumatic brain injury. It is a critical intervention to prevent secondary brain injury, supporting neurological recovery by stabilizing intracranial dynamics effectively.
Choice E reason: Stool softeners prevent straining during bowel movements, which increases intrathoracic and intracranial pressure. In traumatic brain injury, straining risks exacerbating ICP, potentially causing herniation. This intervention ensures smoother bowel movements, maintaining ICP stability and supporting safe management of brain injury.