A nurse is teaching a client who is to begin taking tamoxifen to treat breast cancer. The nurse should instruct the client to expect which of the following findings as an adverse effect of the medication?

Choice A reason: This is incorrect because the patient may not see a response from the medication for at least six months. The patient should continue taking the medication as prescribed and follow up with the provider regularly.

Choice B reason: This is correct because finasteride can cause birth defects in male fetuses if it is absorbed through the skin or ingested by pregnant women. The patient should wear gloves when handling the tablets and avoid contact with crushed or broken tablets.

Choice C reason: This is incorrect because PSA levels will decrease while taking this medication. PSA stands for prostate-specific antigen, which is a marker for prostate cancer. The patient should inform the provider that they are taking finasteride before having a PSA test, as it may affect the results.

Choice D reason: This is incorrect because grapefruit juice does not interact with finasteride. However, the patient should avoid alcohol and other medications that may affect the liver while taking finasteride.

Choice A reason: This is incorrect because withholding all medications may cause hyperglycemia or ketoacidosis in the patient, especially if they are taking insulin or sulfonylureas. The nurse should consult with the prescriber to adjust the dose or timing of the medications according to the patient's blood glucose level and the duration of the procedure.

Choice B reason: This is correct because contacting the prescriber to clarify orders is the best action by the nurse, as the prescriber can provide specific instructions on how to manage the patient's oral antidiabetic drugs before and after the oral endoscopy. The nurse should also monitor the patient's blood glucose level closely and report any abnormal findings to the prescriber.

Choice C reason: This is incorrect because administering half the original dose may not be appropriate for the patient, as it may cause hypoglycemia or hyperglycemia depending on the type and dose of the medication and the patient's blood glucose level. The nurse should not make any changes to the medication regimen without the prescriber's approval.

Choice D reason: This is incorrect because giving the medication with a sip of water may violate the NPO status of the patient, which is necessary to prevent aspiration or interference with the oral endoscopy. The nurse should not administer any oral medications or fluids to the patient unless the prescriber allows it.