A nurse is teaching a client who has angina about nitroglycerin sublingual tablets. Which of the following statements should the nurse include in the teaching?

Choice A reason: Bradycardia is not an adverse effect of diphenhydramine. Bradycardia is a slow heart rate, usually below 60 beats per minute. Diphenhydramine is an antihistamine that blocks the effects of histamine, a chemical that causes allergic reactions. Diphenhydramine does not affect the heart rate, although it may cause palpitations or irregular heartbeat in some cases.

Choice B reason: Constipation is an adverse effect of diphenhydramine. Constipation is a condition in which the bowel movements are infrequent, hard, or difficult to pass. Diphenhydramine has anticholinergic properties, which means it inhibits the activity of acetylcholine, a neurotransmitter that regulates the smooth muscle contraction in the gastrointestinal tract. Diphenhydramine can reduce the intestinal motility and cause constipation, as well as dry mouth, blurred vision, and urinary retention.

Choice C reason: Hypertension is not an adverse effect of diphenhydramine. Hypertension is a condition in which the blood pressure is abnormally high, usually above 140/90 mmHg. Diphenhydramine does not affect the blood pressure, although it may cause orthostatic hypotension, which is a sudden drop in blood pressure when changing positions from lying to standing. This can cause dizziness, fainting, or falls.

Choice D reason: Sedation is an adverse effect of diphenhydramine. Sedation is a state of reduced alertness, awareness, or responsiveness. Diphenhydramine can cross the blood-brain barrier and affect the central nervous system, causing drowsiness, fatigue, impaired coordination, and reduced mental performance. Diphenhydramine can also potentiate the effects of alcohol and other sedatives, such as benzodiazepines, opioids, or barbiturates. The nurse should advise the client to avoid driving, operating machinery, or performing other tasks that require attention and concentration while taking diphenhydramine.

Choice A reason: Taking only one dose of nitroglycerin is not a good advice, as it may not be enough to relieve the angina pain and prevent a myocardial infarction. Nitroglycerin is a vasodilator that relaxes the blood vessels and improves the blood flow to the heart. The recommended dose is one tablet or spray under the tongue every 5 minutes for up to three doses, or until the pain is relieved. Taking only one dose may compromise the effectiveness of the medication and the safety of the client.

Choice B reason: Asking the provider to prescribe a different medication is not a necessary action, as nitroglycerin is a first-line treatment for stable angina and has proven benefits for reducing mortality and morbidity. Changing the medication may not be appropriate or feasible, as there may not be a suitable alternative that has the same efficacy and safety profile. The client should continue taking nitroglycerin as prescribed, unless the provider decides otherwise.

Choice C reason: Saying that there's nothing that can be done to relieve the headaches is not a true or helpful statement, as there are some measures that can help reduce or prevent the headaches. Headaches are a common and expected side effect of nitroglycerin, as it dilates the blood vessels in the brain and causes increased intracranial pressure. However, the headaches usually subside over time as the body adapts to the medication. The client can also take a mild analgesic, such as acetaminophen or ibuprofen, to relieve the headache, as long as it does not interact with the nitroglycerin or other medications.

Choice D reason: Trying to take a mild analgesic to relieve the headache is a reasonable and appropriate suggestion, as it can help alleviate the discomfort and improve the quality of life of the client. The client should choose an analgesic that is safe and effective, such as acetaminophen or ibuprofen, and follow the directions on the label. The client should also consult the provider or the pharmacist before taking any over-the-counter medications, as some of them may interact with nitroglycerin or other medications. The client should also avoid aspirin, as it may increase the risk of bleeding.