A nurse is teaching a client who has a new prescription for simvastatin. Which of the following instructions should the nurse include?
You should take the medication in the morning.
You should avoid grapefruit juice.
You should monitor for ringing in the ears.
You should expect brown-colored urine.
The Correct Answer is B
Choice A reason: Taking the medication in the morning is not the correct instruction. Simvastatin is a statin drug that lowers cholesterol levels by inhibiting the enzyme that produces cholesterol in the liver. The liver produces more cholesterol at night, so simvastatin is more effective when taken in the evening or at bedtime.
Choice B reason: Avoiding grapefruit juice is the correct instruction. Grapefruit juice can increase the blood levels of simvastatin and cause serious side effects such as muscle damage, liver damage, and kidney failure. Grapefruit juice inhibits the enzyme that metabolizes simvastatin in the intestine, leading to higher concentrations of the drug in the bloodstream.
Choice C reason: Monitoring for ringing in the ears is not the correct instruction. Ringing in the ears, or tinnitus, is not a common or serious side effect of simvastatin. However, some other medications that lower cholesterol, such as niacin and gemfibrozil, can cause tinnitus. The client should report any unusual or persistent symptoms to the prescriber.
Choice D reason: Expecting brown-colored urine is not the correct instruction. Brown-colored urine, or hematuria, is not a normal or expected side effect of simvastatin. However, it may indicate a serious condition such as rhabdomyolysis, which is a rare but life-threatening complication of statin therapy. Rhabdomyolysis is the breakdown of muscle tissue that releases a protein called myoglobin into the bloodstream. Myoglobin can damage the kidneys and cause brown-colored urine. The client should seek immediate medical attention if they notice any signs of rhabdomyolysis, such as muscle pain, weakness, fever, or dark urine.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is ["A","B","D"]
Explanation
Choice A reason: Removing the patch for 10 to 12 hours daily is a correct instruction. This allows the client to have a nitrate-free period, which prevents the development of tolerance to the medication. Tolerance reduces the effectiveness of nitroglycerin in relieving anginal pain. The client should remove the patch at night, when the risk of angina is lower, and apply a new patch in the morning.
Choice B reason: Applying the patch to a hairless area and rotating sites is a correct instruction. This prevents skin irritation and enhances absorption of the medication. The client should avoid applying the patch to areas that are exposed to heat, sunlight, or friction, as these factors can increase the release of nitroglycerin and cause hypotension.
Choice C reason: Applying a new patch at the onset of anginal pain is not a correct instruction. Transdermal nitroglycerin is used for the prevention, not the treatment, of anginal attacks. The onset of action of transdermal nitroglycerin is slow, and it may take several hours to reach peak effect. The client should use sublingual nitroglycerin, which has a rapid onset of action, to treat acute anginal pain.
Choice D reason: Applying a new patch each morning is a correct instruction. This ensures that the client has a steady and adequate supply of nitroglycerin throughout the day, when the risk of angina is higher. The client should apply the patch to a different site each day, and remove the old patch before applying the new one.
Choice E reason: Applying the patch to dry skin and covering the area with plastic wrap is not a correct instruction. This can cause skin maceration, which is the softening and breaking down of the skin due to moisture. This can increase the risk of infection and reduce the absorption of the medication. The client should apply the patch to clean and dry skin, and avoid covering the area with any dressing or tape.
Correct Answer is C
Explanation
Choice A reason: "I'll be sure to eat more foods with vitamin K." is not the correct statement. Vitamin K is a nutrient that helps the blood to clot. Warfarin is an anticoagulant that inhibits the action of vitamin K and prevents the formation of blood clots. Eating more foods with vitamin K can counteract the effect of warfarin and increase the risk of thrombosis. The client should maintain a consistent intake of vitamin K and avoid sudden changes in their diet.
Choice B reason: "I'll take aspirin for my headaches." is not the correct statement. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits platelet aggregation and prolongs bleeding time. Taking aspirin with warfarin can increase the risk of bleeding and bruising. The client should avoid taking any NSAIDs without consulting their provider. The client should use acetaminophen or other non-NSAID pain relievers for their headaches.
Choice C reason: "I'll use my electric razor for shaving." is the correct statement. Using an electric razor for shaving can reduce the risk of cuts and bleeding. The client should avoid using sharp objects or instruments that can cause injury or trauma. The client should also use a soft toothbrush and floss gently to prevent bleeding gums.
Choice D reason: "It's okay to have a couple of glasses of wine with dinner each evening." is not the correct statement. Alcohol can interact with warfarin and affect its metabolism and effectiveness. Drinking alcohol with warfarin can either increase or decrease the blood levels of warfarin and alter the international normalized ratio (INR), which is a measure of the blood's clotting ability. The client should limit their alcohol intake and monitor their INR regularly.
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